Computers are really very simply put together. They only understand two responses: yes or no, expressed as 1 or 0 in binary. Using logic operations, this can be used to program calculations and their results. Biological systems behave in a similar way: a stimulus acts on an ensemble of molecules, setting off defined chemical reactions. This analogy inspired I. Willner and his co-workers to use a combination of coupled enzymes to construct a simple circuit in which enzymatic reactions correspond to logic operations.