How Does the Antitumor Drug Get to the Cell Nucleus?

Platinum complexes such as the well-known cisplatin are powerful antitumor medications. They cross the cell membrane and reach the nucleus, where they attach to DNA and stop cell growth. But how does cisplatin get to the nucleus? Italian researchers have now proven that a copper transport protein may play a critical role. In the journal Angewandte Chemie, they present their hypothesis about the transport mechanism.

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<p><a href="http://www.physorg.com/news112946388.html">How Does the Antitumor Drug Get to the Cell Nucleus?</a></p> <p>Platinum complexes such as the well-known cisplatin are powerful antitumor medications. They cross the cell membrane and reach the nucleus, where they attach to DNA and stop cell growth. But how does cisplatin get to the nucleus? Italian researchers have now proven that a copper transport protein may play a critical role. In the journal <i>Angewandte Chemie</i>, they present their hypothesis about the transport mechanism.</p>