Levels of prion protein in brain may not be reliable marker for disease

Rapid diagnostic testing used to check for the presence of prion diseases such as “mad cow disease” might fail to identify some highly infectious samples, researchers have found. Currently, scanning beef or other meat products for possible prion infection involves sampling brain tissue from the animal for abnormally folded prion protein, also called PrP; this form of PrP, which is sticky and hard to degrade, is believed to be the infectious agent behind prion diseases.

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