Type 1 diabetes triggered by 'lazy' regulatory T-cells

A research team led by Dr. Ciriaco A. Piccirillo of McGill University’s Department of Microbiology and Immunology has discovered that in some individuals, the specialized immunoregulatory T-cells that regulate the body’s autoimmune reactions may lose their effectiveness and become “lazy” over time, leading to the onset of type 1 diabetes. The study – conducted on non-obese diabetic (NOD) mice, which were genetically engineered to model human diabetes – was published in the January 2008 edition of the journal Diabetes.

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<p><a href="http://www.physorg.com/news119547855.html">Type 1 diabetes triggered by 'lazy' regulatory T-cells</a></p> <p>A research team led by Dr. Ciriaco A. Piccirillo of McGill University’s Department of Microbiology and Immunology has discovered that in some individuals, the specialized immunoregulatory T-cells that regulate the body’s autoimmune reactions may lose their effectiveness and become “lazy” over time, leading to the onset of type 1 diabetes. The study – conducted on non-obese diabetic (NOD) mice, which were genetically engineered to model human diabetes – was published in the January 2008 edition of the journal <i>Diabetes</i>.</p>