Cougars have been under siege in the United States since the arrival of European settlers, victims of extirpation campaigns and habitat destruction as inhabitants converted wilderness to farmland and pasture. These campaigns eliminated Puma concolor in the East (save for a remnant population in Florida) during the 1880s, and now the same forces—abetted by good intentions—are threatening existing populations in Washington State. A new story in this week’s issue of the open-access journal PLoS Biology shows that good intentions are no substitute for sound science.