Massachusetts General Hospital (MGH) researchers – in collaboration with scientists at the University of California at San Diego and Yale University – have discovered perhaps the strongest evidence yet linking variation in a particular gene with anxiety-related traits. In the March issue of Archives of General Psychiatry, the team describes finding that particular versions of a gene that affects the activity of important neurotransmitter receptors were more common in both children and adults assessed as being inhibited or introverted and also were associated with increased activity of brain regions involved in emotional processing.