Depression is not always manifested in children as dejection and anhedonia. Depending on the age of the child, the dominant features may be weeping, irritability or defiance, as explained by Prof. Claudia Mehler-Wex and Dr. Michael Kölch of Ulm University in the new edition of Deutsches Ärzteblatt International (Dtsch Arztebl Int 2008; 105(9): 149-55).