Work-related fatigue is a common complaint encountered by the occupational physician in the industrialized societies. Most past investigations of work-related fatigue focused on age, subjective discomforts, social-economical factors or on work styles. However, the association between work-related fatigue and general objective health measures, such as liver function tests, metabolic syndrome components (waist circumference, blood pressure, sugar and lipids profile) or hematology test results are yet to be declared among the modern workplaces in Taiwan.