Novel basis identified for tamoxifen failure

Tamoxifen may worsen breast cancer in a small subset of patients. Research published in BioMed Central's open access journal Breast Cancer Research suggests that in patients who show reduced or absent expression of the protein E-cadherin, commonly used anti-oestrogen drugs such as tamoxifen may promote more harmful cancer cell behaviour.

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<p><a href="http://www.physorg.com/news147587111.html">Novel basis identified for tamoxifen failure</a></p> <p>Tamoxifen may worsen breast cancer in a small subset of patients. Research published in BioMed Central's open access journal <I>Breast Cancer Research</I> suggests that in patients who show reduced or absent expression of the protein E-cadherin, commonly used anti-oestrogen drugs such as tamoxifen may promote more harmful cancer cell behaviour.</p>