USA300--the major epidemic strain of methicillin-resistant Staphylococcus aureus (MRSA) causing severe infections in the United States during the past decade--inherits its destructiveness directly from a forefather strain of the bacterium called USA500 rather than randomly acquiring harmful genes from other MRSA strains. This finding comes from a new study led by scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.