New findings highlight the role of endothelial cell activation in children with cerebral malaria

Researchers have identified a novel pathway that may contribute to the high mortality associated with severe malaria in sub-Saharan African children. The study, published March 20 in the open-access journal PLoS Pathogens, reports that severe Plasmodium falciparum infection results in disruption of the endothelium, causing release of ultra-large von Willebrand factor (VWF) protein. Together with reduced levels of VWF-specific cleaving enzyme ADAMTS13, this finding may contribute to our knowledge of the pathophysiology of malaria.

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<p><a href="http://www.physorg.com/news156783415.html">New findings highlight the role of endothelial cell activation in children with cerebral malaria</a></p> <p>Researchers have identified a novel pathway that may contribute to the high mortality associated with severe malaria in sub-Saharan African children. The study, published March 20 in the open-access journal <i>PLoS Pathogens</i>, reports that severe Plasmodium falciparum infection results in disruption of the endothelium, causing release of ultra-large von Willebrand factor (VWF) protein. Together with reduced levels of VWF-specific cleaving enzyme ADAMTS13, this finding may contribute to our knowledge of the pathophysiology of malaria.</p>