How to get obese mice moving -- and cure their diabetes

Mice lacking the fat hormone leptin or the ability to respond to it become morbidly obese and severely diabetic—not to mention downright sluggish. Now, a new study in the June Cell Metabolism shows that blood sugar control in those animals can be completely restored by returning leptin sensitivity to a single class of neurons in the brain, which account for only a small fraction of those that normally carry the hormone receptors.

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<p><a href="http://www.physorg.com/news163164889.html">How to get obese mice moving -- and cure their diabetes</a></p> <p>Mice lacking the fat hormone leptin or the ability to respond to it become morbidly obese and severely diabetic—not to mention downright sluggish. Now, a new study in the June <i>Cell Metabolism</i> shows that blood sugar control in those animals can be completely restored by returning leptin sensitivity to a single class of neurons in the brain, which account for only a small fraction of those that normally carry the hormone receptors.</p>