Generation of a severe memory-deficit mutant mouse by exclusively eliminating the kinase activity of CaMKIIalpha

A Japanese research group, led by Dr. Yoko Yamagata of the National Institute for Physiological Sciences, has successfully generated a novel kinase-dead mutant mouse of the CaMKIIalpha gene that completely and exclusively lacks its kinase activity. They examined hippocampal synaptic plasticity and behavioral learning of the mouse, and found a severe deficit in both processes. They reported their findings in Journal of Neuroscience on June 10, 2009.

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<p><a href="http://www.physorg.com/news164625012.html">Generation of a severe memory-deficit mutant mouse by exclusively eliminating the kinase activity of CaMKIIalpha</a></p> <p>A Japanese research group, led by Dr. Yoko Yamagata of the National Institute for Physiological Sciences, has successfully generated a novel kinase-dead mutant mouse of the CaMKIIalpha gene that completely and exclusively lacks its kinase activity. They examined hippocampal synaptic plasticity and behavioral learning of the mouse, and found a severe deficit in both processes. They reported their findings in <i>Journal of Neuroscience</i> on June 10, 2009.</p>