Portal hypertension is responsible for severe and often lethal complications of cirrhosis. Another important syndrome is hepatic encephalopathy as a consequence of acute and chronic liver failure, which is characterized by a wide spectrum of neuropsychiatric abnormalities. A study group from Argentina analyzed the participation in these syndromes of glutamine synthetase and glutamate uptake in the hippocampus and frontal cortex, by using the prehepatic PH rat model.