Studies led by Dartmouth Medical School researchers have revealed a crucial link in how the immune system works. In a study published online on August 20 in the journal Nature, the researchers found that mast cells, known for their role in allergy reactions such as watery eyes and runny noses, are connected to the activity of regulatory T cells, which suppress immune responses. The researchers say theirs is the first study to find that mast cells mediate immune system suppression.