A simple feedback resistor switch keeps latent HIV from awakening

Upon entering a cell, a virus often becomes dormant, turning off its genes and laying low until awakened by som e trigger from its environment. When that trigger is pulled, the virus quickly ramps up production of proteins through built-in positive-feedback loops that turn up gene transcription. (In positive feedback, production of something stimulates more production of that thing, resulting in exponential, or faster, growth.) If the viral environment were perfectly regulated and viral gene expression perfectly silenced during latency, this system would be foolproof.

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<p><a href="http://www.physorg.com/news86330416.html">A simple feedback resistor switch keeps latent HIV from awakening</a></p> <p>Upon entering a cell, a virus often becomes dormant, turning off its genes and laying low until awakened by som e trigger from its environment. When that trigger is pulled, the virus quickly ramps up production of proteins through built-in positive-feedback loops that turn up gene transcription. (In positive feedback, production of something stimulates more production of that thing, resulting in exponential, or faster, growth.) If the viral environment were perfectly regulated and viral gene expression perfectly silenced during latency, this system would be foolproof.</p>