Bioengineering efficient antibiotic biosynthesis in E. coli

The pathways underlying the production of antibiotics are now quite well known. For example, the antibacterial activity of erythromycin, an important polyketide antibiotic precursor, requires the transfer of two unusual sugars called mycarose and desosamine (both glycosyl groups) onto the nonsugar part of the glycoside molecule (macrocyclic aglycone).

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<p><a href="http://www.physorg.com/news89983244.html">Bioengineering efficient antibiotic biosynthesis in E. coli</a></p> <p>The pathways underlying the production of antibiotics are now quite well known. For example, the antibacterial activity of erythromycin, an important polyketide antibiotic precursor, requires the transfer of two unusual sugars called mycarose and desosamine (both glycosyl groups) onto the nonsugar part of the glycoside molecule (macrocyclic aglycone).</p>