Prediction of RNA pseudoknots using heuristic modeling with mapping and sequential folding
September 19, 2007An algorithm utilizing structure mapping and thermodynamics is introduced for RNA pseudoknot prediction. The method finds the minimum free energy in the context of the biological folding direction (5’ to 3’) of RNA sequences.
It also identifies information about the flexibility of the RNA. Mapping methods are used to build and analyze the folded structure and add important 3D structural considerations.
The model suggests that many biological RNA molecules are optimized by natural selection to fold correctly in the natural context and that stable intermediate RNA secondary structure can persist that anticipates pseudoknot formation.
The model will be published in the online, open-access journal PLoS ONE on September 19.
Source: Public Library of Science
-
Genome tree of life is largest yet for seed plants
Dec 15, 2011 |
5 / 5 (1) |
0
-
'Dark matter' of the genome revealed through analysis of 29 mammals
Oct 12, 2011 |
4.6 / 5 (11) |
2
-
New 'genome mining' technique streamlines discovery from nature
Oct 11, 2011 |
5 / 5 (2) |
0
-
Rival, predator, mate: Mapping the molecules that detect chemical cues
Sep 29, 2011 |
not rated yet |
0
-
1001 Genome-Project: On the way to a complete catalog of the Arabidopsis genome
Aug 28, 2011 |
5 / 5 (1) |
0
-
Engineers build first sub-10-nm carbon nanotube transistor
Feb 01, 2012 |
4.9 / 5 (31) |
30
-
Something old, something new: Evolution and the structural divergence of duplicate genes
Jan 31, 2012 |
4.6 / 5 (7) |
1
-
The hidden nanoworld of ice crystals: Revealing the dynamic behavior of quasi-liquid layers
Jan 30, 2012 |
5 / 5 (3) |
1
-
Stock market network reveals investor clustering
Jan 27, 2012 |
3.9 / 5 (23) |
8
-
Of microchemistry and molecules: Electronic microfluidic device synthesizes biocompatible probes
Jan 26, 2012 |
5 / 5 (1) |
0
More news stories
Entire genome of extinct human decoded from fossil
(PhysOrg.com) -- In 2010, Svante Pääbo and his colleagues presented a draft version of the genome from a small fragment of a human finger bone discovered in Denisova Cave in southern Siberia. The ...
Feb 07, 2012 |
4.7 / 5 (58) |
44
|
Why are there so few fish in the Earth's oceans?
(PhysOrg.com) -- A Stony Brook University researcher has found that, contrary to popular belief, there are not plenty of fish in the sea.
Feb 08, 2012 |
4.3 / 5 (17) |
26
|
Miami battling invasion of giant African snails
No one knows how they got there. But an invasion of African giant snails has southern Florida in a panic over potential crop damage, disease and general yuckiness surrounding the slimy gastropods.
Feb 10, 2012 |
4.5 / 5 (2) |
5
Deciding to go left or right: Researchers use device to determine that lower animals can navigate too
For decades, scientists have associated binary decision making — opting to go left or right — with higher-ranking animals, including humans. A team of Harvard researchers, however, is rewriting that ...
Feb 09, 2012 |
4 / 5 (1) |
4
|
Study shows chimps able to understand needs of others
(PhysOrg.com) -- By setting up a unique experiment, a small team of researchers has found that chimpanzees are able to understand need in other chimps, despite their general disinclination to offer aid when ...
Feb 07, 2012 |
5 / 5 (2) |
4
|
Google might launch Drive for cloud storage soon
(PhysOrg.com) -- Google's next big move, according to the Wall Street Journal, is a cloud storage service called Drive. Hardly first to the plate, Google is simply catching up to introducing its cloud reposi ...
Latin America mining boom clashes with conservation
Latin America is experiencing a mining boom as prices rise fuelled by a hike in global demand, but the region is also being hit by a wave of violent protests, strikes and rallies by environmentalists.
Love a click away in Indonesia's Twitter Republic
He was a geeky kid from Yogyakarta, she a glamorous city girl in Jakarta. In a country with one of the world's most vibrant social networking scenes they fell in love on Twitter.
Walney offshore wind farm is world's biggest (for now)
(PhysOrg.com) -- The Walney wind farm on the Irish Sea--characterized by high tides, waves and windy weather--officially opened this week. The farm is treated in the press as a very big deal as the Walney ...
GPS court ruling leaves US phone tracking unclear
A US Supreme Court decision requiring a warrant to place a GPS device on the car of a criminal suspect leaves unresolved the bigger issue of police tracking using mobile phones, legal experts say.
Europeans protest controversial Internet pact
Tens of thousands of people marched in protests in more than a dozen European cities Saturday against a controversial anti-online piracy pact that critics say could curtail Internet freedom.
