First functional insulin-binding protein in invertebrates

April 15, 2008

Insulin-like growth factor (IGF) signaling that helps to regulate mammals’ growth, metabolism, reproduction and longevity is well documented. Now research published in the open access journal Journal of Biology describes the genetic identification of the first functional insulin-like growth factor binding protein (IGFBP) ortholog in invertebrates.

Insulin and insulin-like growth factors (IGFs) signal through a highly conserved pathway and control growth and metabolism in both vertebrates and invertebrates. The well-studied mammalian IGF binding proteins (IGFBPs) do not, however, have obvious sequence homologs in the fruit fly Drosophila.

The discovery of a functional ortholog transforms Drosophila into a powerful model system in which to explore metabolic regulation and presents a significant advance in our understanding of the mechanisms by which the actions of insulin-like peptides are regulated.

A research team led by Ernst Hafen from the Institute of Molecular Systems Biology at the ETH in Zürich, Switzerland, employed a genetic strategy to search for negative insulin/insulin-like growth factor signaling (IIS) regulators in Drosophila. The team identified a new functional insulin-binding protein that acts as an IIS antagonist. Dubbed imaginal morphogenesis protein-late 2 (Imp-L2), the new antagonist binds the Drosophila insulin-like peptide 2 (Dilp2), inhibiting its growth-promoting function. Imp-L2 not only has a role in growth regulation - it is also essential for the dampening of insulin signaling under adverse conditions.

The authors hope that better understanding of Imp-L2’s role in growth control and insulin signaling in Drosophila will ultimately impact on our understanding of the human ortholog IGFBP-7. This has a regulatory role in pathways that impact upon diabetes and cancer. IGFBP-7 acts as a tumor suppressor in a variety of human organs and differs in the C-terminus from the other IGFBPs.

“Since Imp-L2 and the human tumor suppressor IGFBP-7 display sequence homology in their C-terminal immunoglobulin-like domains, we suggest that their common precursor represents an ancestral insulin-binding protein,” says Hafen

Source: BioMed Central


Rank 5 /5 (1 vote)
Tags

Relevant PhysicsForums posts

More news stories

New molecule has potential to help treat genetic diseases and HIV

(PhysOrg.com) -- Chemists at The University of Texas at Austin have created a molecule that's so good at tangling itself inside the double helix of a DNA sequence that it can stay there for up to 16 days before ...

Biology / Plants & Animals

created 46 minutes ago | popularity 5 / 5 (2) | comments 0 | with audio podcast

Integrated pest management recommendations for the southern pine beetle

The southern pine beetle, Dendroctonus frontalis Zimmermann, is a chronic insect pest within pine forests in the southeastern United States. Under favorable environmental and host conditions, it is an agg ...

Biology / Ecology

created 3 hours ago | popularity not rated yet | comments 0

A mitosis mystery solved: How chromosomes align perfectly in a dividing cell

Although the process of mitotic cell division has been studied intensely for more than 50 years, Whitehead Institute researchers have only now solved the mystery of how cells correctly align their chromosomes during symmetric ...

Biology / Cell & Microbiology

created 18 hours ago | popularity 4.5 / 5 (22) | comments 0 | with audio podcast

Researchers find extensive RNA editing in human transcriptome

In a new study published online in Nature Biotechnology, researchers from BGI, the world's largest genomics organization, reported the evidence of extensive RNA editing in a human cell line by analysis of RNA-seq data, demons ...

Biology / Biotechnology

created 18 hours ago | popularity 5 / 5 (4) | comments 0 | with audio podcast

The proteins ensuring genome protection

Researchers from the University of Geneva (UNIGE), Switzerland, have discovered the crucial role of two proteins in developing a cell 'anti-enzyme shield'. This protection system, which operates at the level of molecular ...

Biology / Cell & Microbiology

created 18 hours ago | popularity 5 / 5 (3) | comments 0 | with audio podcast


With climate change, today's '100-year floods' may happen every three to 20 years: research

Last August, Hurricane Irene spun through the Caribbean and parts of the eastern United States, leaving widespread wreckage in its wake. The Category 3 storm whipped up water levels, generating storm surges ...

Social psychologist: Lust makes you smarter and evidence that seven deadly sins are good for you

(Medical Xpress) -- Good news for lovers on Valentine’s Day - the seven deadly sins, including Lust, are good for you. University of Melbourne social psychologist Dr Simon Laham uses modern research to make a compelling ...

The joy of cheques

An electronic cheque which eliminates the need for costly processing by banks but preserves the simplicity and ease of a traditional cheque book has been designed by a team of academics in the UK.

Research shows promise in converting camelina oil into jet fuel

(PhysOrg.com) -- Researchers at Montana State University-Northern have developed a process to convert camelina oil to jet fuel and other high-value chemicals. MSU has applied for a U.S. patent and research is ongoing.

Couples in the same place emotionally stay together, study says

(Medical Xpress) -- Despite life’s ups and downs, couples whose feelings are in sync consistently over time are more likely to stay together, says a University of California, Davis, study.

Researchers make breakthrough in stem cell research

(Medical Xpress) -- University of Queensland scientists have developed a world-first method for producing adult stem cells that will substantially impact patients who have a range of serious diseases.