A New Way to Think About Earth's First Cells
June 5, 2008
Above is a three-dimensional view of a model protocell approximately 100 nanometers in diameter. The protocell's fatty acid membrane allows nutrients and DNA building blocks to enter the cell and participate in non-enzymatic copying of the cell's DNA. The newly formed strands of DNA remain in the protocell. Credit: Janet Iwasa, Szostak Laboratory, Harvard Medical School and Massachusetts General Hospital
A team of researchers at Harvard University have modeled in the laboratory a primitive cell, or protocell, that is capable of building, copying and containing DNA.
Since there are no physical records of what the first primitive cells on Earth looked like, or how they grew and divided, the research team's protocell project offers a useful way to learn about how Earth's earliest cells may have interacted with their environment approximately 3.5 billion years ago.
The protocell's fatty acid membrane allows chemical compounds, including the building blocks of DNA, to enter into the cell without the assistance of the protein channels and pumps required by today's highly developed cell membranes. Also unlike modern cells, the protocell does not use enzymes for copying its DNA.
Supported with funding from the National Science Foundation and led by Jack W. Szostak of the Harvard Medical School, the research team published its findings in the June 4, 2008, edition of the journal Nature's advance online publication.
"Szostak's group took a creative approach to this research challenge and made a significant contribution to our understanding of small molecule transport through membranes," said Luis Echegoyen, director of the NSF Division of Chemistry. "This is a great outcome of NSF's support of basic research."
Some scientists have proposed that ancient hydrothermal vents may have been sites where prebiotic molecules--molecules made before the origin of life, such as fatty acids and amino acids--were formed. An animation (accessible at upper right) created by Janet Iwasa of the Szostak Laboratory shows a theoretical scenario in which fatty acids are formed on the surface of minerals deep underground, and then brought to the surface by the eruption of a geyser.
When fatty acids are in an aqueous environment, they spontaneously arrange so that their hydrophilic, or water-loving, "heads" interact with the surrounding water molecules and their hydrophobic, or water-fearing, "tails" are shielded from the water, resulting in the formation of tiny spheres of fatty acids called micelles.
Depending upon chemical concentrations and the pH of their environment, micelles can convert into layered membrane sheets or enclosed vesicles. Researchers commonly use vesicles to model the cellular membranes of protocells. A second animation created by Iwasa (accessible at lower right) shows how vesicles may have been formed.
When the team started its work, the researchers were not sure that the building blocks required for copying the protocell's genetic material would be able to enter the cell.
"By showing that this can happen, and indeed happen quite efficiently, we have come a little closer to our goal of making a functional protocell that, in the right environment, is able to grow and divide on its own," said Szostak.
Source: National Science Foundation



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How does a man making a cell in a test tube disprove creationism?
Wait a minute! that's right! If man MAKES a cell in a test tube it doesn't prove evolution or abiogenesis! It supports special creation, since it took an intelligent being producing a specific sequence of DNA and a specific sequence of finely controlled conditions to produce anything other than lifeless goo...
Evolutionist:
"We created life in a test tube, this PROVES creation isn't true..."
idiocy...
Like a tank filled with water and various minerals or chemicals and probed with electricity (simulating lightning), or something.
If complex proteins begin to develop while doing something like this, then it would indeed prove that life can originate independently.
And yes, scientists are creating these neat little thingies in a lab, but they are doing it by modelling natural processes. And every time they discover something new, the God Of The Gaps gets squeezed more and more.
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Key word here = "Modeled"
Some interesting things about this word:
1) Implies intelligent creation and/or design
2) Implies a representation or simulation of another thing, and not the thing itself
So the atheistic notion that you are "merely" throwing some things in a tank and turning on the juice is misleading.
As I stated, creating a cell in a laboratory is, by definition, Intelligent Design. It is not at all proof of evolution or abiogenesis.
By definition, neither science nor religion can prove or disprove the existence of God, in spite of what lots of scientists and preachers say.
Now drop the creationist/evolutionist foolishness before your ignorance of religion becomes embarrassingly obvious.
NOT A New Way to Think About Earth's First Cells
Just Probing Small Molecule Transport Through Membranes
http://www.physor...452.html
This work report concludes with a strange deluded statement:
"By showing that this can happen, and indeed happen quite efficiently, we have come a little closer to our goal of making a functional protocell that, in the right environment, is able to grow and divide on its own"
This is another glaring case that demonstrates why science must be rescued from the guild(s) of "professional science (mostly) technicians and (very few) scientists".
Unbelievable that in the 21st century "scientists" regard a cell as an organism. This is like regarding a future space station as an organism. Unbelievable!
Dov Henis
http://www.physfo...ic=14988&st=225entry347345
http://blog.360.y...Q--?cq=1