Is yakult helpful in the treatment of irritable bowel syndrome?

September 10, 2008

SIBO is a common feature in IBS and in fact may be directly related to the genesis of IBS symptoms. An ERBHAL on a lactulose breath test may indicate SIBO. Antibiotics and elemental diets have been shown to be effective in treating SIBO, but the efficacy of probiotics is untested. A pilot study was undertaken to determine the effect of L. strain Shirota (Yakult(R)) on intestinal fermentation patterns of IBS patients.

After 6 week of treatment with 1 x 65 mL dose of Yakult(R) daily, 9 of 14 patients (64%) completing the study had reversal of ERBHAL, with the median time of first rise increasing from 45 to 75 min (P = 0.03). Furthermore, symptoms improved in those in whom ERBHAL was corrected. The results indicate that Yakult(R) alters fermentation patterns suggesting a reduction in SIBO. ERBHAL can also indicate rapid small intestinal transit and therefore, in order to confirm the effect of Yakult(R) on SIBO, future studies will include monitoring of transit time in addition to placebo control.

A research article to be published on August 28, 2008 in the World Journal of Gastroenterology addresses this question. The research team was led by Peter Gibson and his colleagues at Monash University, Box Hill Hospital. The pilot trial was undertaken to determine whether a probiotic could have an effect on SIBO. Currently, SIBO is managed by antibiotics and/or elemental diets, the side effects and practicalities of which make them undesirable options. Probiotics may provide a safe alternative. The results of the pilot trial warrant a well powered, double blind, placebo-controlled trial.

The effect of probiotics on SIBO had not previously been investigated, but after taking Yakult(R) daily for 6 wk, there was a significant shift in the time of first rise on the lactulose breath test indicating a reduction in SIBO. If these findings are confirmed by further research, Yakult(R) may be a safe and effective alternative for the management of this patient group.

Article: http://www.wjgnet.com/1007-9327/14/5020.asp

Source: World Journal of Gastroenterology

• fuchikoma - Sep 13, 2008
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  Dannon Danactive seems to be almost the same thing, but much easier to find in North America. Instead of Yakult's Lactobacillus Casei Shirota, Danactive uses a strain called Lactobacillus Casei Defensis or Immunitas, which supposedly boosts the immune system.
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• Keter - Sep 13, 2008
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  The behaviors of one culture vs. another in vivo can be quite different. Not only are there different strains, there are different sub-cultures within strains (your lacto may be different from my lacto). One strain or culture may work better for one person and not as well for another, so a degree of experimentation may be called for until these interactions are better understood.
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