Candidate markers for gastric cancer

October 29, 2008

The sequencing of the human genome has opened the door for proteomics by providing a sequence-based framework for mining proteomes. As a result, there is intense interest in applying proteomics to foster a better understanding of cancer processes, develop new biomarkers for diagnosis and early detection of cancer. Gastric carcinoma is one of the most common malignancies worldwide and is the most common cause of cancer-related death in China. The main barrier for improving survival rate is short of useful marker for early diagnosis.

A research article to be published on October 7, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Professor Liu from Ruijin Hospital of China isolated and identified differentially expressed proteins between cancer and normal tissues of gastric cancer by 2-DE and MALDI-TOF-MS.

Total proteins were isolated from tumor and normal tissues and then separated by 2-DE. Differentially expressed proteins were isolated and identified by MALDI-TOF or MALDI-TOF-TOF-MS. Twenty three differentially expressed proteins were found between tumor and normal tissues of gastric cancer, among these fifteen proteins were identified. These differential proteins will be candidate markers for gastric cancer. It may be useful for diagnosis, treatment target and prognosis.

Source: World Journal of Gastroenterology

Filter


Move the slider to adjust rank threshold, so that you can hide some of the comments.


Display comments: newest first

E_L_Earnhardt
Oct 30, 2008

Rank: 1 / 5 (1)
DRINK COLD WATER!
Rank 5 /5 (1 vote)
Relevant PhysicsForums posts
  • Is Everyday Technology Killing Us?
    createdFeb 08, 2012
  • Exercise and weight loss
    createdFeb 08, 2012
  • Why do we have head aches? Our brains can't feel anything.
    createdFeb 07, 2012
  • "The end of diseases" by David Agus, interview from Daily Show with Jon Stewart
    createdFeb 04, 2012
  • Oncolytic adenovirus
    createdFeb 04, 2012
  • Nutrition label stuffs and diets
    createdFeb 02, 2012
  • More from Physics Forums - Medical Sciences

More news stories

Cognitive impairment in older adults often unrecognized in the primary care setting

A new study published in the Journal of the American Geriatrics Society reveals that brief cognitive screenings combined with offering further evaluation increased new diagnoses of cognitive impairment in older veterans two to ...

Medicine & Health / Diseases

created 57 minutes ago | popularity not rated yet | comments 0

Primary care program helps obese teen girls manage weight, improve body image and behavior

Teenage girls gained less weight, improved their body image, ate less fast food, and had more family meals after participating in a 6- month program that involved weekly peer meetings, consultations with primary care providers ...

Medicine & Health / Health

created 47 minutes ago | popularity not rated yet | comments 0

Botox developer rues missing out on billions

Botox developer Alan Scott says he rues the day he handed over rights to the best-selling wrinkle-smoothing drug to a US company for just $4.5 million, saying he might have become a billionaire.

Medicine & Health / Medications

created 1 hour ago | popularity not rated yet | comments 0

Young adults allowed to stay on parents' health insurance have improved access to care

Researchers from Mount Sinai School of Medicine have found that laws permitting children to stay on their parents' health insurance through age 26 result in improved access to health care compared to states without those ...

Medicine & Health / Health

created 1 hour ago | popularity not rated yet | comments 0

Cancer rate 4 times higher in children with juvenile arthritis

New research reports that incident malignancy among children with juvenile idiopathic arthritis (JIA) is four times higher than in those without the disease. Findings now available in Arthritis & Rheumatism, a journal publis ...

Medicine & Health / Diseases

created 1 hour ago | popularity not rated yet | comments 0


Rapunzel, Leonardo and the physics of the ponytail

(PhysOrg.com) -- New research provides the first mathematical understanding of the shape of a ponytail and could have implications for the textile industry, computer animation and personal care products.

AT&T customers surprised by 'unlimited data' limit

(AP) -- Mike Trang likes to use his iPhone 4 as a GPS device, helping him get around in his job. Now and then, his younger cousins get ahold of it, and play some YouTube videos and games.

Climate change causes harmful algal blooms in North Atlantic: study

Warming oceans and increases in windiness could be causing of an abundance of harmful algal blooms in the North Atlantic Ocean and North Sea, according to new research.

Hacker claims porn site users compromised

A hacker claims to have compromised the personal information of more than 350,000 users after breaking into a disused website operated by pornography provider Brazzers.

Integrated pest management recommendations for the southern pine beetle

The southern pine beetle, Dendroctonus frontalis Zimmermann, is a chronic insect pest within pine forests in the southeastern United States. Under favorable environmental and host conditions, it is an agg ...

Scientists discover molecular secrets of 2,000-year-old Chinese herbal remedy

For roughly two thousand years, Chinese herbalists have treated Malaria using a root extract, commonly known as Chang Shan, from a type of hydrangea that grows in Tibet and Nepal. More recent studies suggest that halofuginone, ...