Low-glycemic diet shows greater improvement in glycemic control than high-fiber diet

December 17, 2008

Persons with type 2 diabetes who had a diet high in low-glycemic foods such as nuts, beans and lentils had greater improvement in glycemic control and risk factors for coronary heart disease than persons on a diet with an emphasis on high-cereal fiber, according to a study in the December 17 issue of JAMA.

One dietary strategy aimed at improving both diabetes control and cardiovascular risk factors is the use of low–glycemic index diets, but there is disagreement over their effectiveness, according to background information in the article.

David J. A. Jenkins, M.D., of St. Michael's Hospital and the University of Toronto, and colleagues assessed the effects of a low–glycemic index diet vs. a high–cereal fiber diet on glycemic control and cardiovascular risk factors for 210 patients with type 2 diabetes. The participants, who were treated with antihyperglycemic medications, were randomly assigned to receive 1 of the 2 diet treatments for 6 months.

In the low–glycemic index diet, the following foods were emphasized: beans, peas, lentils, nuts, pasta, rice boiled briefly and low–glycemic index breads (including pumpernickel, rye pita, and quinoa and flaxseed) and breakfast cereals (including large flake oatmeal and oat bran). In the high–cereal fiber diet, participants were advised to take the "brown" option (whole grain breads; whole grain breakfast cereals; brown rice; potatoes with skins; and whole wheat bread, crackers, and breakfast cereals). Three servings of fruit and five servings of vegetables were encouraged on both treatments.

The researchers found that hemoglobin A1c (HbA1c; a substance of red blood cells tested to measure the blood glucose level) decreased by ��.50 percent absolute HbA1c units in the low–glycemic index diet compared with ��.18 percent absolute HbA1c units in the high–cereal fiber diet. Significant treatment effects were observed for high-density lipoprotein cholesterol (HDL-C) and the low-density lipoprotein cholesterol (LDL-C):HDL-C ratio. HDL-C increased in the low–glycemic index diet group by 1.7 mg/dL and decreased by ��.2 mg/dL in the high–cereal fiber diet group. The LDL-C:HDL-C ratio showed a greater reduction in the low–glycemic index diet group compared with the high–cereal fiber diet group.

"Lowering the glycemic index of the diet improved glycemic control and risk factors for coronary heart disease (CHD). These data have important implications for the treatment of diabetes where the goal has been tight glycemic control to avoid complications. The reduction in HbA1c was modest, but we think it has clinical relevance," the authors write. "Low–glycemic index diets may be useful as part of the strategy to improve glycemic control in patients with type 2 diabetes taking antihyperglycemic medications."

"Pharmacological interventions to improve glycemic control in type 2 diabetes have often failed to show a significant reduction in cardiovascular events. In view of the 2- to 4-fold increase in CHD risk in participants with type 2 diabetes, the ability of a low–glycemic index diet to address both glycemic control and CHD risk factors increases the clinical relevance of this approach for patients with type 2 diabetes, such as those in this study, who are overweight and also taking statins for CHD risk reduction."

Paper: JAMA. 2008;300[23]:2742-2753.

Source: JAMA and Archives Journals


print this article email this article download pdf blog this article bookmark this article     Stumble it Digg this share on Facebook retweet share on Reddit add to delicious
Rate this story - 2.5 /5 (2 votes)

Rank Filter

Move the slider to adjust rank threshold, so that you can hide some of the comments.


Display comments: newest first

  • bredmond - Dec 17, 2008
    • Rank: not rated yet
    Id like to eat more beans, but they give me gas. Many sources have voodoo cures. Does anybody know how to make beans without causing gas?

December 17, 2008 all stories

Comments: 1

2.5 /5 (2 votes)
  • Stumble this up

  • Digg this

  • share this

  • hide
  • Related Stories

  • A 'spoonful of sugar' makes the worms' life span go down
    created Nov 03, 2009 | popularity not rated yet | comments 0
  • Acne really is a nightmare for some teens
    created Sep 16, 2009 | popularity not rated yet | comments 0
  • Medicine wheel model for nutrition shows promise for control of type 2 diabetes
    created Sep 09, 2009 | popularity not rated yet | comments 0
  • Your arteries on Wonder bread
    created Jun 25, 2009 | popularity not rated yet | comments 0
  • Omega-3 fatty acids appear to impact age-related macular degeneration progression
    created Jun 18, 2009 | popularity not rated yet | comments 0



  • hide
  • Relevant PhysicsForums posts

  • How to prevent another stroke?
    created Nov 11, 2009
  • Swine flu vaccination
    created Nov 10, 2009
  • Improving the brain through chemistry
    created Nov 07, 2009
  • Sleep / REM Sleep and homeostasis
    created Nov 07, 2009
  • More from Physics Forums - Medical Sciences

Other News

Study: Can meditation sharpen our attention?

Medicine & Health / Neuroscience

created 23 hours ago | popularity 3.4 / 5 (5) | comments 3

(PhysOrg.com) -- A new study at the University of Wisconsin-Madison suggests that people can train their minds to stay focused.


When preschoolers ask questions, they want explanations

Medicine & Health / Psychology & Psychiatry

created 22 hours ago | popularity 4 / 5 (2) | comments 2

Curiosity plays a big part in preschoolers' lives. A new study that explored why young children ask so many "why" questions concludes that children are motivated by a desire for explanation.


'Cross-talk' mechanism contributes to colorectal cancer

Medicine & Health / Cancer

created 20 hours ago | popularity 5 / 5 (1) | comments 0

Researchers at the University of Wisconsin-Madison School of Medicine and Public Health have identified a molecular mechanism that allows two powerful signaling pathways to interact and begin a process leading to colorectal ...


Shape perception in brain develops by itself

Medicine & Health / Psychology & Psychiatry

created 20 hours ago | popularity 5 / 5 (1) | comments 0

Despite minimal exposure to the regular geometric objects found in developed countries, African tribal people perceive shapes as well as westerners, according to a new study.


Thoughtful words help couples stay fighting fit

Medicine & Health / Psychology & Psychiatry

created 19 hours ago | popularity not rated yet | comments 0

Couples who bring thoughtful words to a fight release lower amounts of stress-related proteins, suggesting that rational communication between partners can ease the impact of marital conflict on the immune system.