'Silver nanoparticle' microscope may shed new light on cancer, bone diseases

Their study is scheduled for the March issue of ACS’ Nano Letters.

In the new study, John Lupton and colleagues point out that one of the most powerful, widely used tools for imaging hidden biological structures is fluorescence microscopy, which requires the specimen to be treated with fluorescent dyes or stains. But the dyes used to visualize the structures can kill living cells, limiting the effectiveness of the technique, the researchers note.

The scientists improved on this technique by using an infrared laser to excite clusters of silver nanoparticles, each about 1/5000th the width of a human hair, placed below the material being studied. The particles focus intense beams of light up through the sample to reveal information about the composition and structure of the substance examined, the scientists say. In laboratory studies, they used the new technique to view the iridescent green scales of the so-called “photonic beetle,” whose scales may provide clues to designing new, more powerful solar cells and computer chips, the scientists say.

Provided by ACS