In double transplant, left hand works first

April 7, 2009 By RANDOLPH E. SCHMID , AP Science Writer

(AP) -- When patients had both hands transplanted, their brains re-established connections much more quickly with the left hand than the right, a team of researchers in France reports.

The sample was small, just two patients, but both had been right-handed before losing their hands, and both followed a pattern of reconnection with their that was quicker for the left hand.

The study, led by Angela Sirigu of the Center for at the University of Lyon, France, is reported in Tuesday's edition of Proceedings of the National Academy of Science.

The research shows that even years after the loss of hands the brain can reorganize and rewire itself to recognize and connect to a replacement.

And it comes just days after French physicians, in a 30-hour operation, performed the world's first simultaneous partial-face and double-hand transplant. Paris' Public Hospital authority described the recipient as a 30-year-old burn victim who was injured in a 2004 accident.

Sirigu's team used magnetic imaging to study the brains of people who had lost both hands and to see how the motor region that controls movement responded after new hands were transplanted.

The first case involved LB, a 20-year-old man injured in 2000, who received the transplants in 2003 after having used artificial hand devices in the meantime.

He was checked periodically and the researchers found his brain had re-established nerve connections to control the left hand by 10 months, while it took 26 months to complete the rewiring needed for the right hand.

"Interestingly, despite that LB was right-handed, and that after his amputation he used his prosthetic device mostly with his right hand, hand preference shifted from right to left after he had the graft," the researchers reported.

The second patient studied, CD, was a 46-year-old man who lost both hands in 1996 and received a dual hand transplant in 2000. He was tested by the researchers in 2004, 51 months after the transplants. Strong connections in the brain were observed for the left hand, but not yet the right.

The researchers said more study is needed to determine why the brain reconnected more efficiently to the left hand in these patients. Possibilities include a basically better connection to the left hand, factors in the way that the brain reorganizes itself during the process of the loss of a hand and its later replacement, or perhaps some pre-existing difference in brain organization.

In general, experiments have shown that the right side of the brain controls the left side of the body and many researchers believe it also dominates in such areas as spatial abilities, face recognition, visual imagery and music. The left side of the brain controls the right side of the body and is thought to dominate in language, math and logic. However, many traits are shared by both sides, and if one side is damaged the other can take over many of its functions.

The research was supported by the U.S. National Science Foundation, the French National Center for Scientific Research, the International Brain Organization and other organizations in Brazil, France and Canada.

---

On the Net:

Proceedings of the National Academy of Science: http://www.pnas.org

©2009 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


Rank not rated yet
Related Stories
Relevant PhysicsForums posts
  • Is Everyday Technology Killing Us?
    createdFeb 08, 2012
  • Exercise and weight loss
    createdFeb 08, 2012
  • Why do we have head aches? Our brains can't feel anything.
    createdFeb 07, 2012
  • "The end of diseases" by David Agus, interview from Daily Show with Jon Stewart
    createdFeb 04, 2012
  • Oncolytic adenovirus
    createdFeb 04, 2012
  • Nutrition label stuffs and diets
    createdFeb 02, 2012
  • More from Physics Forums - Medical Sciences

More news stories

Injured boomers beware: Know when to see doctor

(AP) -- It happened to nurse Jane Byron years after an in-line skating fall, business owner Haralee Weintraub while doing "men's" push-ups, and avid cyclist Gene Wilberg while lifting a heavy box.

Medicine & Health / Health

created 1 hour ago | popularity not rated yet | comments 0

FDA-approved drug rapidly clears amyloid from the brain, reverses Alzheimer's symptoms in mice

Neuroscientists at Case Western Reserve University School of Medicine have made a dramatic breakthrough in their efforts to find a cure for Alzheimer's disease. The researchers' findings, published in the journal Science, show t ...

Medicine & Health / Neuroscience

created Feb 09, 2012 | popularity 4.9 / 5 (53) | comments 21 | with audio podcast

Green tea found to reduce disability in the elderly

(Medical Xpress) -- A lot of research has been done over the past several years looking into the health benefits of green tea. As a result, scientists have found that regular consumption of the beverage leads ...

Medicine & Health / Health

created Feb 07, 2012 | popularity 4.4 / 5 (14) | comments 11 | with audio podcast report

Teen school drop-outs three times as likely to be on benefits in later life

Teen school drop-outs are almost three times as likely to be on benefits in later life as their peers who complete their schooling, indicates research published online in the Journal of Epidemiology and Community Health.

Medicine & Health / Health

created Feb 06, 2012 | popularity not rated yet | comments 13

To perform with less effort, practice beyond perfection

Whether you are an athlete, a musician or a stroke patient learning to walk again, practice can make perfect, but more practice may make you more efficient, according to a surprising new University of Colorado Boulder study.

Medicine & Health / Neuroscience

created Feb 09, 2012 | popularity 4.4 / 5 (15) | comments 6 | with audio podcast


Google might launch Drive for cloud storage soon

(PhysOrg.com) -- Google's next big move, according to the Wall Street Journal, is a cloud storage service called Drive. Hardly first to the plate, Google is simply catching up to introducing its cloud reposi ...

Latin America mining boom clashes with conservation

Latin America is experiencing a mining boom as prices rise fuelled by a hike in global demand, but the region is also being hit by a wave of violent protests, strikes and rallies by environmentalists.

Love a click away in Indonesia's Twitter Republic

He was a geeky kid from Yogyakarta, she a glamorous city girl in Jakarta. In a country with one of the world's most vibrant social networking scenes they fell in love on Twitter.

Europeans protest controversial Internet pact

Tens of thousands of people marched in protests in more than a dozen European cities Saturday against a controversial anti-online piracy pact that critics say could curtail Internet freedom.

Walney offshore wind farm is world's biggest (for now)

(PhysOrg.com) -- The Walney wind farm on the Irish Sea--characterized by high tides, waves and windy weather--officially opened this week. The farm is treated in the press as a very big deal as the Walney ...

Navy to begin tests on electromagnetic railgun prototype launcher

The Office of Naval Research (ONR)'s Electromagnetic (EM) Railgun program will take an important step forward in the coming weeks when the first industry railgun prototype launcher is tested at a facility ...