Controlling our brain's perception of emotional events

Lauzon, a Doctoral graduate student in the Laviolette laboratory, discovered that specific receptors for the neurotransmitter dopamine can control how the brain processes emotionally significant information as well as memories for those experiences. Using a rodent model of emotional learning and memory formation, the researchers found by increasing the activity of a specific dopamine receptor in a region of the brain called the pre-frontal cortex, it was able to transform a normally insignificant emotional experience into a very strong emotional memory. In contrast, when a different subtype of the dopamine system was activated, it was able to block the ability to recall an emotionally charged experience.

"Our findings have profound implications for understanding how specific brain receptors can control the magnitude of emotional experience and memory formation," says Laviolette.

"Targeting these receptor systems pharmacologically may offer new therapeutic treatments for controlling the emotional perception and memory deficits observed in psychiatric disorders such as Schizophrenia and PTSD." Laviolette is a professor in the Department of Anatomy & Cell Biology and a National Alliance for Research on Schizophrenia and Depression (NARSAD) Young Investigator.

According to the National Institute of Mental Health, over 280,000 Canadians suffer from Schizophrenia, and approximately 51 million people worldwide.

About eight per cent of the population will have PTSD symptoms at some point in their lives according to the National Center for Post-Traumatic Stress Disorder in the United States.

Source: University of Western Ontario