Our brains make their own marijuana: We're all pot heads deep inside
April 20, 2009U.S. and Brazilian scientists have just proven that one of Bob Dylan's most famous lines—"everybody must get stoned"— is correct. That's because they've discovered that the brain manufactures proteins that act like marijuana at specific receptors in the brain itself. This discovery, published online in The FASEB Journal, may lead to new marijuana-like drugs for managing pain, stimulating appetite, and preventing marijuana abuse.
"Ideally, this development will lead to drugs that bind to and activate the THC receptor, but are devoid of the side effects that limit the usefulness of marijuana," said Lakshmi A. Devi of the Department of Pharmacology and Systems Therapeutics at Mount Sinai School of Medicine in New York and one of the senior researchers involved in the study. "It would be helpful to have a drug that activated or blocked the THC receptor, and our findings raise the possibility that this will lead to effective drugs with fewer side effects."
Scientists made their discovery by first extracting several small proteins, called peptides, from the brains of mice and determining their amino acid sequence. The extracted proteins were then compared with another peptide previously known to bind to, but not activate, the receptor (THC) affected by marijuana. Out of the extracted proteins, several not only bound to the brain's THC receptors, but activated them as well.
"The War on Drugs has hit very close to home," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "Last year, scientists found that our skin makes its own marijuana-like substance. Now, we see that our brain has been making proteins that act directly on the marijuana receptors in our head. The next step is for scientists to come up with new medicines that eliminate the nasty side of pot—a better joint, so to speak."
More information: Ivone Gomes, Julia S. Grushko, Urszula Golebiewska, Sascha Hoogendoorn, Achla Gupta, Andrea S. Heimann, Emer S. Ferro, Suzanne Scarlata, Lloyd D. Fricker, and Lakshmi A. Devi. Novel endogenous peptide agonists of cannabinoid receptors. FASEB J. doi:10.1096/fj.09-132142 http://www.fasebj. … .09-132142v1
Source: Federation of American Societies for Experimental Biology (news : web)
-
The body's own 'marijuana' is good for the skin
Jul 02, 2008 |
not rated yet |
0
-
Marijuana increases alcohol toxicity in young rats
Apr 08, 2008 |
not rated yet |
0
-
How do cannabinoids make us feel that way?
Oct 09, 2007 |
not rated yet |
0
-
Prune juice not necessary: New research should make bowel movements easier
Apr 08, 2009 |
not rated yet |
0
-
New research tracks effects of addictive drugs on brain
May 16, 2008 |
not rated yet |
0
-
Engineers build first sub-10-nm carbon nanotube transistor
Feb 01, 2012 |
4.9 / 5 (31) |
30
-
Something old, something new: Evolution and the structural divergence of duplicate genes
Jan 31, 2012 |
4.6 / 5 (7) |
1
-
The hidden nanoworld of ice crystals: Revealing the dynamic behavior of quasi-liquid layers
Jan 30, 2012 |
5 / 5 (3) |
1
-
Stock market network reveals investor clustering
Jan 27, 2012 |
3.9 / 5 (23) |
8
-
Of microchemistry and molecules: Electronic microfluidic device synthesizes biocompatible probes
Jan 26, 2012 |
5 / 5 (1) |
0
-
Is Everyday Technology Killing Us?
Feb 08, 2012
-
Exercise and weight loss
Feb 08, 2012
-
Why do we have head aches? Our brains can't feel anything.
Feb 07, 2012
-
"The end of diseases" by David Agus, interview from Daily Show with Jon Stewart
Feb 04, 2012
-
Oncolytic adenovirus
Feb 04, 2012
-
Nutrition label stuffs and diets
Feb 02, 2012
- More from Physics Forums - Medical Sciences
More news stories
Complex wiring of the nervous system may rely on a just a handful of genes and proteins
Researchers at the Salk Institute have discovered a startling feature of early brain development that helps to explain how complex neuron wiring patterns are programmed using just a handful of critical genes. ...
7 hours ago |
4.9 / 5 (9) |
0
|
Both maternal and paternal age linked to autism
Older maternal and paternal age are jointly associated with having a child with autism, according to a recently published study led by researchers at The University of Texas Health Science Center at Houston (UTHealth).
Medicine & Health / Psychology & Psychiatry
12 hours ago |
4.3 / 5 (3) |
0
|
New understanding of DNA repair could eventually lead to cancer therapy
A research group in the Faculty of Medicine & Dentistry at the University of Alberta is hoping its latest discovery could one day be used to develop new therapies that target certain types of cancers.
11 hours ago |
4.8 / 5 (5) |
0
|
Curry spice component may help slow prostate tumor growth
Curcumin, an active component of the Indian curry spice turmeric, may help slow down tumor growth in castration-resistant prostate cancer patients on androgen deprivation therapy (ADT), a study from researchers ...
13 hours ago |
4.4 / 5 (8) |
0
|
Team isolates nerve cells involved in storing long term memory and gene proteins associated with them
(Medical Xpress) -- A research team in Taiwan has succeeded in isolating two nerve cells in fruit fly brains that are believed to be the major players in allowing for the formation of long term memories. Furthermore, ...
Anonymous knocks CIA website offline (Update)
The website of the Central Intelligence Agency was inaccessible on Friday after the hacker group Anonymous claimed to have knocked it offline.
Google users warned of threat to smartphone wallets
Users of Google smartphone wallets were being warned on Friday that there is a way to crack pass codes intended to thwart thieves from going on illicit shopping sprees.
New error-correcting codes guarantee the fastest possible rate of data transmission
Error-correcting codes are one of the triumphs of the digital age. Theyre a way of encoding information so that it can be transmitted across a communication channel such as an optical fiber o ...
Humans may have helped the decline of African rainforests 3000 years ago
(PhysOrg.com) -- Large areas of rainforests in Central Africa mysteriously disappeared over three thousand years ago, to be replaced by savannas. The prevailing theory has been that the cause was a change ...
The power of estrogen -- male snakes attract other males
A new study has shown that boosting the estrogen levels of male garter snakes causes them to secrete the same pheromones that females use to attract suitors, and turned the males into just about the sexiest ...
New power source discovered
(PhysOrg.com) -- Researchers at the Massachusetts Institute of Technology (MIT) and RMIT University have made a breakthrough in energy storage and power generation.
Apr 20, 2009
Rank: not rated yet
Apr 20, 2009
Rank: not rated yet
If you WANT the high, it's fine with me.
Apr 20, 2009
Rank: 1 / 5 (2)
Apr 21, 2009
Rank: not rated yet
Apr 21, 2009
Rank: not rated yet
Jul 26, 2009
Rank: 1 / 5 (1)