Rosiglitazone does not harm bone healing if combined with metformin in rats
June 11, 2009Taking the diabetes medications metformin and rosiglitazone together reverses the adverse effects on bone of rosiglitazone treatment alone in an experimental model, according to a new study done in rats.
Both metformin and rosiglitazone are widely used in the treatment of type 2 diabetes and the metabolic syndrome, said lead author Claudia Sedlinsky, MD, of GIOMM - La Plata National University, La Plata, Buenos Aires, Argentina.
Recent research, however, shows that rosiglitazone decreases bone mineral density in healthy humans and appears to increase fractures in women with type 2 diabetes, compared with those receiving metformin or another diabetes medication.
Previously, Sedlinsky's group reported that metformin helps grow bone cells in laboratory cultures. They wanted to find out if metformin could have beneficial effects on bone healing in an animal model and to compare it with rosiglitazone.
Sedlinsky and her colleagues tested four groups of rats that had a small hole in a bone. One group of rats received only metformin in their drinking water, a second group got only rosiglitazone, a third group received both medications and the last group—the controls—received plain water with no drug (placebo). After 30 days of treatment, the researchers removed the injured bone from the animals and studied it for evidence of new bone formation.
As expected, metformin increased bone healing and rosiglitazone decreased bone healing compared with placebo (no treatment). However, in the rats that received combined treatment, metformin completely reversed the ability of rosiglitazone to inhibit new bone formation, the authors found. Bone healing was similar to that observed in control rats.
Further investigations are needed to know whether these results can translate to humans, Sedlinsky stressed.
"This important finding may lead to further investigations about how to treat patients with anti-diabetic drugs while avoiding potential harm to their bones," she said.
-
Long-term use of diabetes drugs by women significantly increases risk of fractures
Dec 10, 2008 |
not rated yet |
0
-
No 'convincing evidence' that glitazones work better than older diabetes drugs
Apr 10, 2008 |
not rated yet |
0
-
Diabetes drug slows early-onset puberty in girls
Jun 16, 2008 |
not rated yet |
0
-
Diabetes medication associated with slower progression of retina disease
Jun 09, 2008 |
not rated yet |
0
-
Meta-analysis examines cardiovascular effects of diabetes medications
Oct 27, 2008 |
not rated yet |
0
-
Engineers build first sub-10-nm carbon nanotube transistor
Feb 01, 2012 |
4.9 / 5 (33) |
30
-
Something old, something new: Evolution and the structural divergence of duplicate genes
Jan 31, 2012 |
4.6 / 5 (7) |
1
-
The hidden nanoworld of ice crystals: Revealing the dynamic behavior of quasi-liquid layers
Jan 30, 2012 |
5 / 5 (4) |
1
-
Stock market network reveals investor clustering
Jan 27, 2012 |
3.9 / 5 (23) |
8
-
Of microchemistry and molecules: Electronic microfluidic device synthesizes biocompatible probes
Jan 26, 2012 |
5 / 5 (2) |
0
-
Is Everyday Technology Killing Us?
Feb 08, 2012
-
Exercise and weight loss
Feb 08, 2012
-
Why do we have head aches? Our brains can't feel anything.
Feb 07, 2012
-
"The end of diseases" by David Agus, interview from Daily Show with Jon Stewart
Feb 04, 2012
-
Oncolytic adenovirus
Feb 04, 2012
-
Nutrition label stuffs and diets
Feb 02, 2012
- More from Physics Forums - Medical Sciences
More news stories
Declining health-care productivity in England: Who says so?
Reports that the National Health Service in England has been declining in productivity in the last decade appear to have been accepted as fact. However, a Viewpoint published Online First by The Lancet disputes this. The Vi ...
47 minutes ago |
not rated yet |
0
Overeating may double risk of memory loss
New research suggests that consuming between 2,100 and 6,000 calories per day may double the risk of memory loss, or mild cognitive impairment (MCI), among people age 70 and older. The study was released today and will be ...
Medicine & Health / Neuroscience
2 hours ago |
5 / 5 (2) |
0
|
Starve a virus, feed a cure? Findings show how some cells protect themselves against HIV
A protein that protects some of our immune cells from the most common and virulent form of HIV works by starving the virus of the molecular building blocks that it needs to replicate, according to research published online ...
6 hours ago |
5 / 5 (1) |
0
|
Injured boomers beware: Know when to see doctor
(AP) -- It happened to nurse Jane Byron years after an in-line skating fall, business owner Haralee Weintraub while doing "men's" push-ups, and avid cyclist Gene Wilberg while lifting a heavy box.
7 hours ago |
5 / 5 (1) |
0
FDA-approved drug rapidly clears amyloid from the brain, reverses Alzheimer's symptoms in mice
Neuroscientists at Case Western Reserve University School of Medicine have made a dramatic breakthrough in their efforts to find a cure for Alzheimer's disease. The researchers' findings, published in the journal Science, show t ...
Medicine & Health / Neuroscience
Feb 09, 2012 |
4.9 / 5 (58) |
15
|
Scientists discover molecular secrets of 2,000-year-old Chinese herbal remedy
For roughly two thousand years, Chinese herbalists have treated Malaria using a root extract, commonly known as Chang Shan, from a type of hydrangea that grows in Tibet and Nepal. More recent studies suggest that halofuginone, ...
New method to examine batteries -- MRI from the inside
There is an ever-increasing need for advanced batteries for portable electronics, such as phones, cameras, and music players, but also to power electric vehicles and to facilitate the distribution and storage of energy derived ...
A mitosis mystery solved: How chromosomes align perfectly in a dividing cell
Although the process of mitotic cell division has been studied intensely for more than 50 years, Whitehead Institute researchers have only now solved the mystery of how cells correctly align their chromosomes during symmetric ...
Lab study raises questions over nano-particle impact
Tests involving chickens have raised questions about the impact on health from engineered nano-particles, the ultra-fine grains commonly used in drugs and processed foods, scientists said on Sunday.
Google might launch Drive for cloud storage soon
(PhysOrg.com) -- Google's next big move, according to the Wall Street Journal, is a cloud storage service called Drive. Hardly first to the plate, Google is simply catching up to introducing its cloud reposi ...
Researchers find extensive RNA editing in human transcriptome
In a new study published online in Nature Biotechnology, researchers from BGI, the world's largest genomics organization, reported the evidence of extensive RNA editing in a human cell line by analysis of RNA-seq data, demons ...