Cannabis alters human DNA
June 16, 2009
A new study published by University of Leicester researchers has found "convincing evidence" that cannabis smoke damages DNA in ways that could potentially increase the risk of cancer development in humans.
Using a newly developed highly sensitive liquid chromatography-tandem mass spectrometry method, the University of Leicester scientists found clear indication that cannabis smoke damages DNA, under laboratory conditions.
They have now published the findings in the journal Chemical Research in Toxicology.
The research was carried out by Rajinder Singh, Jatinderpal Sandhu, Balvinder Kaur, Tina Juren, William P. Steward, Dan Segerback and Peter B. Farmer from the Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine and Karolinska Institute, Sweden.
Raj Singh said: “Parts of the plant Cannabis sativa, also known as marijuana, ganja, and various street names, are commonly smoked as a recreational drug, although its use for such purposes is illegal in many countries.
“There have been many studies on the toxicity of tobacco smoke. It is known that tobacco smoke contains 4000 chemicals of which 60 are classed as carcinogens. Cannabis in contrast has not been so well studied. It is less combustible than tobacco and is often mixed with tobacco in use. Cannabis smoke contains 400 compounds including 60 cannabinoids. However, because of its lower combustibility it contains 50% more carcinogenic polycyclic aromatic hydrocarbons including naphthalene, benzanthracene, and benzopyrene, than tobacco smoke.”
Writing in the journal Chemical Research in Toxicology, the scientists describe the development of a mass spectrometry method that provides a clear indication that cannabis smoke damages DNA, under laboratory conditions.
The authors added: “It is well known that toxic substances in tobacco smoke can damage DNA and increase the risk of lung and other cancers. Scientists were unsure though whether cannabis smoke would have the same effect. Our research has focused on the toxicity of acetaldehyde, which is present in both tobacco and cannabis.”
The researchers add that the ability of cannabis smoke to damage DNA has significant human health implications especially as users tend to inhale more deeply than cigarette smokers, which increases respiratory burden. "The smoking of 3-4 cannabis cigarettes a day is associated with the same degree of damage to bronchial mucus membranes as 20 or more tobacco cigarettes a day," the team adds.
"These results provide evidence for the DNA damaging potential of cannabis smoke," the researchers conclude, "implying that the consumption of cannabis cigarettes may be detrimental to human health with the possibility to initiate cancer development."
Citation: Rajinder Singh, Jatinderpal Sandhu, Balvinder Kaur, Tina Juren, William P. Steward, Dan Segerback and Peter B. Farmer (2009) Evaluation of the DNA Damaging Potential of Cannabis Cigarette Smoke by the Determination of Acetaldehyde Derived N2-Ethyl-2′-deoxyguanosine Adducts. Chemical Research in Toxicology, 22, 1181-1188.
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Jun 16, 2009
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Jun 16, 2009
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That's how we learned that tobacco causes cancer - the rate of cancer mirrored the rate of tobacco use. But we *don't* see this happening with cannabis! Cannabis use goes up - cancer rates are unchanged, cannabis use goes down - cancer rates are unchanged.
I'm going to bet that this exciting new discovery is discredited in the near future.
If cannabis really did "alter human dna" and cause cancer then, after more than **5,000 years** of continuous use we'd know all about it by now. We wouldn't be needing "highly sensitive liquid chromatography-tandem mass spectrometry methods under laboratory conditions" to find it out now!
If cannabis truly is so deadly that we really do need a perpetual world-wide prohibition of it, causing more than 2,000 arrests in this country every day and more than 6,000 brutal murders a year, then it'd be blatantly obvious every time we looked in the faces of the poor saps who use it. We wouldn't be needing hair and pee tests just to determine whether a person has consumed cannabis or not!
But it's not obvious at all. Law enforcement can't tell whether a driver is under the influence of cannabis or not - they don't have puss oozing from the face or are drooling green stuff from the mouth. They don't have open lesions forming over 90% of their bodies or are tearing at their faces to remove the imaginary spiders that are crawling over them. There are no signs at all apart perhaps from a sweet smell in the air and possibly diluted pupils. Big deal!
Jun 16, 2009
Rank: 3.3 / 5 (4)
You're getting too excited! Have a break, smoke one!
Perhaps we can blame cannabis for some portion of the cancer that we used to blame tobacco for. Many of the cigarette smokers use to smoke cannabis too. But they do not promptly confirm when asked.
Jun 16, 2009
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Jun 16, 2009
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Jun 16, 2009
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Acetaldehyde is an oxidation product of alcohol - so you drinkers better watch out !
Anybody tried vapourising alchohol ?
:)
Jun 16, 2009
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Jun 16, 2009
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Thats it :-)
However, consider using an electronic one, the non-electric ones do not work very well in my opinion.
Jun 16, 2009
Rank: 3 / 5 (2)
Jun 16, 2009
Rank: 2.3 / 5 (3)
As for the Vaps... use electric. The burn ones are good but too unstable.
Jun 16, 2009
Rank: 3.7 / 5 (3)
Whats worse, a beer after work, or a bowl?
A pot head or an alcholic?
Engage research.
Jun 16, 2009
Rank: 3.7 / 5 (3)
No facts such as how many overblown impossible parts per million (or was it parts per three.)of acetaldehyde they used on the poor rats.
Jun 16, 2009
Rank: 3.7 / 5 (3)
Money. I am willing to give them benefit of the doubt and say: money and ignorance.
Kungfublood has the right of it I think.
Jun 16, 2009
Rank: 5 / 5 (2)
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Why does every article on marijuana feel the need to print this, or some variant? Is there anyone alive on the planet who still doesn't know what marijuana is?
Jun 16, 2009
Rank: 4 / 5 (4)
A good example of this is when CNN writes an article about NASA installing a toilet on the International Space Station. For some reason they feel it necessary to tell us that "NASA launched Apollo 11 in 1969", and that "the Challenger explosion killed 7 people". Tell me, how is any of that relevant to a story about a new toilet?
Jun 16, 2009
Rank: 4.3 / 5 (7)
Even putting aside the DNA damage for a moment, the fine particulate matter that results from all forms of combustion is not good for your lungs. Doesn't matter whether it is smoke from a power plant, car, or a joint, it's going to harm you.
There are other ways to take marijuana. If you're going to use that drug, then take the time to research the most effective (and safest) method of consumption.
Jun 16, 2009
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Jun 16, 2009
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Jun 16, 2009
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Jun 16, 2009
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http://www.huffin...712.html
or the studies that found THC actually has an anti-cancer effect....
http://safeaccess...ncer.htm
all this aside from the fact that cannabis completely alleviates the nausea caused by chemotherapy.
more fear-mongering bunk paid for by big pharma.
Jun 16, 2009
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Jun 17, 2009
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Jun 17, 2009
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Jun 17, 2009
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Jun 17, 2009
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I call BULLSH*T on this article. It was discovered in the not too distant past that our skin itself is comprised in a very small part of THC (it was said that if you smoked all the skin on your body, you still wouldnt be even close to getting a buzz..so basically our skin is weaker dirt weed)..
If Marijuana alters DNA, that entails that THC is the likely candidate to be doing the alterations. So if THC can make alteration to DNA, then why doesnt our skin change color periodically w/o an outside force (such as a tanning bed or the sun)...bad example I know, but the point is, if THC altered DNA, then our own skin would be altering its own DNA, and my HEAVY smoking habits would have by now royally screwed up something....
I personally can't stand vapo's...I need the consistency of the smoke in my mouth, to let it roll out and breathe it into my nose, while I softly stroke my glass "jar o' bud" and tell mary how much I love her...lol
Now, give me a nice freakin Gravitron and its on like donkey kong :) Yea, you guys know hat I'm talkin about ;)
Vlasev-I think youre being too liberal in saying we can blame some on my sweet mary. I will say, MAYBE nose or throat cancer, merely from smoke instead of oxygen passing through your airways...
however, the last I heard, resins from mary jane break down in your lungs naturally, where cigarette tar/resin does not. Since the big offender with smoking is lung cancer, I would say it is still a better treatment than a hinderance to health. WE all know the medical benfits (just like uncle sam who doesn't want to admit that our freakin economy would be fixed instantly via legalization of marijuana for medicinal and recreational use).
iknow-I am always asked how the hell I can burn down a couple Gs of some $40 a gram shit, then sit down and program or perform things like domain migrations while baked. I always answer the same way...I was baked when I learned it, so I'm baked when I do it :)
pzcom-shit man, we actually got it easy in the US...I cant remember exactly which country, but it was one of the tiny hole in the wall asian countries...but if them fkrs catch you with even a roach, youre freakin executed (true story, read it in the magazine of the highest times, in an article about penalties for gettin blazed across the globe).
thailand if i remember right canes you multiple times and locks you away for like 10 yrs for even as small as a roach.
another out there freakin cuts your hand off or some shite....
gopher-they should change the background info to something more like "man, i cant wait to piss in that toilet...and then drink my piss" :D
On your second comment, are you sure youre not confusing DNA alteration with organ damage? It would take a long long time completely submersed in a room filled to the point of thickness you cant see through for many years on end to alter the DNA I think. After all, that ties right into evolution and adapation (and putting it VERY simple here so no ripping me a new asshole guys)...you have to be exposed to something consistently over long periods to adapt at the genetic level like that. You don't go underwater and breathe through any gills right, cuz you'd have to be exposed to that water for 10s of millions of years before that adaptation occurred, and even then, there has to be something under that water you REALLY cant do without to even bring that about. The aprticulates and such you speak of get stuck in, and can damage, the lung in most cases. BUT, if you consider that any smokers lungs are coated internally with resin/tar, it is only logical that those particulates that are breathed in get stuck to the resins, and not to your tissue directly, thereby allowing some leniency in its effect. In the case of mary, well, her resins break down naturally in our lungs, so the question really becomes, do those particulates break down with the resin in the lungs, or do they remain and then attach....?!
codesuidae-this ist good research, this is just another bullshit excuse theyre coming up with to hold us down from truly being free. You are not free when someone has the LEGAL (key word there) right to dictate how the hell you live your life. I GUARANTEE you, within 2 months, we will see an article directly contradicting this, and from a better lab with better equipment and more renowned scientists. So then which has the gopod research, the ones giving the government their excuses, or the ones who are unbiast and want the truth out there?
degojoey-fuck yea :D
mattytheory-now you know someone who does. In fact, that is VERY light smoking. I average, and honestly this is pretty low estimate, probably 12-18 bowls a day...on my pipe, that equates to 3-5 grams a day basically (and I smoke like $200 a quarter named shit from the highest times magazine, no shittin either, thank dog I can trade computer work for smoke :D )...and that is just to myself. When my wife joins me, tack 4 bowls on top of that (another gram basically).
dig-the amount you smoke does NOT amount to problems. thats kind of ignorant to think that in fact. I can absolutely positively guarantee you that you and I could be sitting next to each other in a meeting having a deep technical discussion and you would never even know I got baked before the meeting. I have the advantage that my eyes dont get bloodshot...
But anyways, there is not 1 person in my entire family that doesnt smoke more than this. Even my grandma and grandpa before they died smoked more than this (and they swore by the fact it helped them after strokes).
Jun 17, 2009
Rank: 1 / 5 (3)
A.N.U.S. (Americans for a New United States)
take our government back NOW by force if necessary!
Jun 18, 2009
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Jun 18, 2009
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Jun 18, 2009
Rank: 5 / 5 (4)
The "suggestion of some protective effect" is the part that sticks out in my mind. How could non-bias research that has been going on for decades show this, yet it damages DNA and causes cancer?
Jun 18, 2009
Rank: not rated yet
I love the fact that on a website for brilliant minds that no one is against the original higher thinking
Thats fantastic, .. it solves the problem!
All we need is a daily complement, 'brilliant minds'!
Costs nothing .. makes you feel great and no negative health effects! WONDERFUL.
Saves all you guys the time and effort .. eh? :)
Keep it simple .... the more complex you get the harder it is to pass on in a learning long term ... and folk with baD vibes get to hide rubbish between the lines easier.
We all have the things we really need, do we want/need more? Is progress a way to control/destroy what is actually our only lifeline?
Jun 18, 2009
Rank: 3.7 / 5 (3)
Keith Richards will survive a nuclear blast along with the roaches and old Volvos. He's been very well hardened. ;-)
If MJ replaced alcohol as the substance of choice for people, instead of riots in the street after sporting events, we'd have sing ins. Wife beaters would become wife lovers, DUI accidents would be LOW SLOW IMPACT.
On a serious note. Glaucoma and a plethora of other conditions are improved with the use of marijuana as a medical treatment. Big Pharma overseas tried some time ago to use its active ingredients, put it in a capsule to sell, no luck. Opiate use for people in chronic pain including diabetic neuropathy, cancer and other mean nasty vexing conditions is reduced helping those poor souls in a tangible and healthier way. Those who suffer from lower appetites, weight loss from disease are also assisted by marijuana.
The problem is government would have to admit they lied, so it isn't going to happen. People can and will ABUSE any substance be it legal or illegal. Everything from glue, paint, sugar any substance available natural, legal or not will be abused. Perhaps a little stress reduction will provide less cardiovascular disease, less inflammatory disease and slow down our frenetic lives enough to enjoy those marvelous unquantifiable parts of life which provide us with enjoyment of those nice flowers blooming in the park.
Jun 20, 2009
Rank: 5 / 5 (2)
Jun 21, 2009
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Jun 21, 2009
Rank: 5 / 5 (2)
Guess what: No matter how dangerous something is, you can't stop me, or anyone else, from doing it. My decisions are mine, not yours, and I'll be damned if I let you determine them.
I will eat my carcinogenic, fat-filled cheeseburger, smoke my joint, and have anal sex with with my closest cousin (at the same time) because he enjoys it so much, just to spite you. I might even die because of my decisions, and there's not a goddamned thing you can do about it, and one day, when the Nazi Puritans are out of office, it just might be legal too.
Jun 21, 2009
Rank: 5 / 5 (2)
Jun 21, 2009
Rank: not rated yet
It only serves propaganda.
I agree with the facts stated above by jway.
It is "sledgehammer science" that proves the obvious.
Obviously, some chemicals in smoke could damage DNA.
However, if cannabis smoking caused cancer,
then there would be an epidemic of potheads
dying of cancer today, and that is not so!!!!!!
Actually, the THC and related molecules have
been demonstrated to prevent or cure cancers.
I agree with lots of other comments above that
vapourizers and/or eating cannabis is superior.
A joint could be called a caveman's vapourizer.
The idea that cannabis should be smoked
is another side-effect of pot prohibition.
What this kind of "scare science" does is
help create headlines to keep growing
the fascist police state powers.
But then, getting funding for "research"
is much easier if one agrees to do that!
Jun 22, 2009
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Jun 22, 2009
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Jun 22, 2009
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you got it all wrong buddy...global warming increases teh marijuanas plants effective habitable ranges thereby leading to more pot smoking by us "damned hippies" thereby leading to our cancer...where the fact we smoked cigs for 10 yrs before the test is ignored :)
So global warming = increase in grow area increase in potheads = increase in cancer
yea...dont add up to me either with all = signs :)