Hepatitis B virus mutations may predict risk of liver cancer

Certain mutations in the DNA of the hepatitis B virus (HBV) are associated with the development of liver cancer and may help predict which patients with HBV infections are at increased risk of the disease, according to a large meta-analysis in the Journal of the National Cancer Institute, published online July 2.

HBV infection is a known cause of hepatocellular (HCC), the most common form of liver . Previous studies have looked at whether patients with specific in the viral DNA may be at increased risk of developing the cancer, but most of the studies were small and they produced conflicting results.

This meta-analysis, conducted by Guangwen Cao, M.D., Ph.D., of the Second Military Medical University in Shanghai and colleagues, included 43 studies with a total of 11,582 HBV-infected participants, of whom 2,801 had HCC. The researchers found that certain mutations were associated with development of HCC and more prevalent as chronic HBV infection progressed from the asymptomatic state to liver cirrhosis or HCC.

"Frequent examination of patients with chronic HBV infections for the presence of these mutations may be useful for identifying which patients require preventive antiviral treatment and for the prediction of HCC," the authors write.

Source: Journal of the National Cancer Institute (news : web)

Citation: Hepatitis B virus mutations may predict risk of liver cancer (2009, July 2) retrieved 29 March 2024 from https://medicalxpress.com/news/2009-07-hepatitis-virus-mutations-liver-cancer.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Diabetes doubles liver cancer risk for patients with advanced hepatitis C

 shares

Feedback to editors