New silver nanoparticle skin gel for healing burns

Kishore Paknikar and colleagues note that antimicrobial silver compounds have been used for decades on burn patients, whose damaged skin is highly vulnerable to bacterial infections. However, topical silver agents now in use can loose effectiveness in the body, cause skin discoloration, and damage cells. Drug-resistant bacteria can make these treatments less effective.

The scientists demonstrated that their gel killed a broad range of harmful bacteria, including Pseudomonas aeruginosa, one of the most common causes of burn infections, as well as several drug-resistant microbes. The gel, which contains 30 times less silver than silver sulfadiazine, did not have any apparent toxic effects when applied to the healthy skin of test animals. "These results clearly indicate that silver nanoparticles could provide a safer alternative to conventional antimicrobial agents in the form of a topical antimicrobial formulation," the article states.

More information: "Silver nanoparticles in therapeutics: development of an antimicrobial gel formulation for topical use" Molecular Pharmaceutics

Source: American Chemical Society (news : web)