Is endotoxin receptor CD14 rs2569190/C-159T gene correlated with chronic hepatitis C?
August 26, 2009It is still unknown why the natural history of chronic disease caused by hepatitis C virus (HCV), which currently infects 3% of the world's population, varies from mild in some patients to rapidly progressing in others.
Age, sex, alcohol consumption and liver sensitivity to gut-derived bacterial endotoxins, were the early factors defined to enhance the risk of fibrosis progression. Host genetic variations, e.g., the CD14 single nucleotide polymorphism (SNP), rs2569190/C-159T, have been recently intensively investigated and suggested to be prognostic factors for cirrhosis in various liver diseases. Is this endotoxin receptor SNP correlated with liver disease features in chronic hepatitis C patients?
A research article to be published on August 21, 2009 in the World Journal of Gastroenterology addresses this question. The research team lead by Professor Sabine Mihm and her colleagues from the Department of Gastroenterology and Endocrinology, University Medical Center Göttingen, Germany, analyzed the distribution of various epidemiological, biochemical, and histological characteristics in 2 cohorts of Caucasian chronic hepatitis C patients with respect to their genotypes according to the CD14 rs2569190/C-159T SNP.
In one cohort, patients who carried 2 variant alleles (TT) were found to be younger than C allele carriers (CC or CT). Among the histological lesions studied, portal lymphoid aggregates were more frequently observed among TT than among C carriers. The presence of portal lymphoid aggregates was also closely correlated with another 2 lesions, moderate and severe hepatic inflammation and the presence of bile duct damage. However, the degree of fibrosis was not found to be related to the CD14 gene C-159T SNP.
The different situation between chronic liver diseases caused by HCV infection or by alcohol consumption in relation to TT status suggests that endotoxin sensitivity depends on both genetic and environmental factors (gene environment interaction). Our analysis suggests, for the first time, a relationship between the CD14 variation and the formation of portal lymphoid aggregates, which was attributed to the host's immunological participation in liver disease pathogenesis.
More information: Askar E, Ramadori G, Mihm S. Endotoxin receptor CD14 genevariants and histological features in chronic HCV infection. World J Gastroenterol 2009; 15(31): 3884-3890 http://www.wjgnet. … /15/3884.asp
-
The risk factors of idiopathic pulmonary fibrosis in HCV patients
Oct 23, 2008 |
not rated yet |
0
-
Hyperferritinemia is another surrogate marker of advanced liver disease
May 13, 2009 |
not rated yet |
0
-
Regular marijuana use increases risk of hepatitis C-related liver damage
Jan 28, 2008 |
not rated yet |
0
-
Attention: Extra-hepatic manifestation of hepatitis C virus infection
Jan 16, 2008 |
not rated yet |
0
-
Do patients at risk for B-cell malignancy need antiviral treatment?
Apr 15, 2009 |
not rated yet |
0
-
Engineers build first sub-10-nm carbon nanotube transistor
Feb 01, 2012 |
4.9 / 5 (33) |
30
-
Something old, something new: Evolution and the structural divergence of duplicate genes
Jan 31, 2012 |
4.6 / 5 (7) |
1
-
The hidden nanoworld of ice crystals: Revealing the dynamic behavior of quasi-liquid layers
Jan 30, 2012 |
5 / 5 (4) |
1
-
Stock market network reveals investor clustering
Jan 27, 2012 |
3.9 / 5 (23) |
8
-
Of microchemistry and molecules: Electronic microfluidic device synthesizes biocompatible probes
Jan 26, 2012 |
5 / 5 (2) |
0
-
Classical and Quantum Mechanics via Lie algebras
Apr 15, 2011
- More from Physics Forums - Independent Research
More news stories
Starve a virus, feed a cure? Findings show how some cells protect themselves against HIV
A protein that protects some of our immune cells from the most common and virulent form of HIV works by starving the virus of the molecular building blocks that it needs to replicate, according to research published online ...
10 hours ago |
5 / 5 (2) |
0
|
Overeating may double risk of memory loss
New research suggests that consuming between 2,100 and 6,000 calories per day may double the risk of memory loss, or mild cognitive impairment (MCI), among people age 70 and older. The study was released today and will be ...
Medicine & Health / Neuroscience
6 hours ago |
5 / 5 (2) |
0
|
Injured boomers beware: Know when to see doctor
(AP) -- It happened to nurse Jane Byron years after an in-line skating fall, business owner Haralee Weintraub while doing "men's" push-ups, and avid cyclist Gene Wilberg while lifting a heavy box.
11 hours ago |
5 / 5 (1) |
0
Declining health-care productivity in England: Who says so?
Reports that the National Health Service in England has been declining in productivity in the last decade appear to have been accepted as fact. However, a Viewpoint published Online First by The Lancet disputes this. The Vi ...
4 hours ago |
not rated yet |
0
FDA-approved drug rapidly clears amyloid from the brain, reverses Alzheimer's symptoms in mice
Neuroscientists at Case Western Reserve University School of Medicine have made a dramatic breakthrough in their efforts to find a cure for Alzheimer's disease. The researchers' findings, published in the journal Science, show t ...
Medicine & Health / Neuroscience
Feb 09, 2012 |
4.9 / 5 (58) |
17
|
Scientists discover molecular secrets of 2,000-year-old Chinese herbal remedy
For roughly two thousand years, Chinese herbalists have treated Malaria using a root extract, commonly known as Chang Shan, from a type of hydrangea that grows in Tibet and Nepal. More recent studies suggest that halofuginone, ...
New method to examine batteries -- MRI from the inside
There is an ever-increasing need for advanced batteries for portable electronics, such as phones, cameras, and music players, but also to power electric vehicles and to facilitate the distribution and storage of energy derived ...
Google might launch Drive for cloud storage soon
(PhysOrg.com) -- Google's next big move, according to the Wall Street Journal, is a cloud storage service called Drive. Hardly first to the plate, Google is simply catching up to introducing its cloud reposi ...
A mitosis mystery solved: How chromosomes align perfectly in a dividing cell
Although the process of mitotic cell division has been studied intensely for more than 50 years, Whitehead Institute researchers have only now solved the mystery of how cells correctly align their chromosomes during symmetric ...
Lab study raises questions over nano-particle impact
Tests involving chickens have raised questions about the impact on health from engineered nano-particles, the ultra-fine grains commonly used in drugs and processed foods, scientists said on Sunday.
Researchers find extensive RNA editing in human transcriptome
In a new study published online in Nature Biotechnology, researchers from BGI, the world's largest genomics organization, reported the evidence of extensive RNA editing in a human cell line by analysis of RNA-seq data, demons ...
