JAX publishes online tool for exploring autoimmune disease gene networks

To help researchers investigate these common pathways, The Jackson Laboratory has published "Pathways to Discovery: Autoimmune Diseases" (www.jax.org/jaxmice/pathways/autoimmune), a unique, interactive, and publicly accessible online resource that illustrates the genetic networks involved in five common autoimmune diseases: inflammatory bowel disease, rheumatoid arthritis, asthma, multiple sclerosis, and psoriasis.

The backbone of the new tool is five "spider-web" diagrams that depict the gene/proteins involved in two or more of the five diseases. The symbols in the diagrams represent cytokines, transmembrane receptors, enzymes, nuclear receptors, and transcriptional regulators. The resource also provides gene- and disease-specific references, links to JAX® Mice strains (including inducible mouse models) that can be used to research the five diseases, and descriptions of JAX® In Vivo Services for compound efficacy testing.

"Pathways to Discovery: Autoimmune Diseases" promises to accelerate the discovery of autoimmune disease mechanisms and therapeutic interventions for both new and existing targets.

Source: Jackson Laboratory