The results are reported by researchers at the San Francisco VA Medical Center and the University of California, San Francisco in the November 2009 issue of the Archives of General Psychiatry.

The researchers, led by Beth E. Cohen, MD, MAS, a staff physician at SFVAMC, looked at an array of perceived effects of heart disease as reported by the study participants, including chest pain frequency and severity, limitations on physical activity and daily functioning, and overall quality of life.

They then measured the participants’ actual cardiac function according to a variety of objective measures: treadmill exercise capacity; left ventricular ejection fraction, which measures how efficiently the heart pumps blood; and inducible ischemia, which measures how much oxygen the heart receives during exercise.

The 95 patients with PTSD reported significantly greater perceived symptom burden, greater physical limitation, and reduced quality of life than those without PTSD, even when their objective measures of cardiac function were equivalent.

The differences in perception remained even after the researchers excluded participants with depression, “which could also be expected to affect how people perceive the severity of their heart disease,” according to Cohen, who is also an assistant professor of medicine at UCSF.

“There is something unique and independent about PTSD that makes heart disease more burdensome, irrespective of actual heart function,” concludes Cohen. “Unfortunately, we can’t venture to speculate what that is without more detailed data.”

The study authors cite a body of research that suggests a PTSD rate of 8 to 12 percent in the general population and 13 to 30 percent among military veterans.

Cohen suggests that for patients with both heart disease and PTSD, “we need to look at not only improving physical measures like cholesterol and blood pressure, but treating the symptoms of PTSD as well. In addition to improving patients’ emotional health, our findings suggest that it may also improve their level of function and quality of life. And that’s what we’d really like to know - how treating PTSD can affect heart health.”

Currently, Cohen’s research team is working on a follow-up study that looks at the same participants five years later. “This will allow us to evaluate if the people with PTSD did worse over time in terms of actual heart outcomes,” she says.

Co-authors of the study were Charles R. Marmar, MD, and Thomas Neylan, MD, of SFVAMC and UCSF, and Nelson B. Schiller, MD, and Sadia Ali, MD, MPH, of UCSF. The senior author was Mary Whooley, MD, of SFVAMC and UCSF.

Provided by University of California, San Francisco