Protein that represses genes may play role in cell growth

(PhysOrg.com) -- A Cornell study shows the protein not only activates some genes involved in the regulation of cell growth and signaling, but also may play a role in preventing cancers by inhibiting cell proliferation.

A protein known for repressing genes has surprised researchers: It not only activates some genes involved in the regulation of and signaling, but also may play a role in preventing cancers by inhibiting .

Published in the journal Genes and Development, the Cornell study finds that the protein macroH2A1 may play previously unknown roles in activating genes. The discovery is surprising, say the researchers, because the protein has long been known to repress genes on one of the two X chromosomes in female mammals.

Female mammals have two X chromosomes with duplicate copies of genes -- one set must be shut down to properly balance the products that those genes express. MacroH2A1 represses on the inactive .

However, the new work shows that macroH2A1 also regulates genes on chromosomes not involved in determining an organism's sex, which are called autosomes, and that it can activate, as well as repress, genes.

"We found that in some repressed regions of autosomes, there are genes that escape repression, and macroH2A1 is actually needed to express those genes," said W. Lee Kraus, professor of and genetics, and the paper's senior author. Mathew Gamble, a former postdoctoral researcher in Kraus' lab and now an assistant professor at Albert Einstein College of Medicine, is the paper's lead author.

MacroH2A1 is classified as a histone variant, which means that it resembles the normal histone proteins that package DNA in the cell's nucleus. But macroH2A1 is extended by an additional protein domain that can bind with other proteins and help them associate with a cell's . Since some forms of this extra "macrodomain" have the ability to bind to small molecules, it may potentially be used as a target where specially designed drugs may bind, said Kraus.

When macroH2A1 is absent, previous studies have reported that cells may lose their ability to shut down and, therefore, grow aberrantly, leading to . Researchers are now using macroH2A1 to predict the risk of lung cancer recurrence.

Provided by Cornell University
Citation: Protein that represses genes may play role in cell growth (2009, December 21) retrieved 29 March 2024 from https://medicalxpress.com/news/2009-12-protein-represses-genes-role-cell.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Newly-discovered mechanism can explain the Beckwith-Wiedemann syndrome

 shares

Feedback to editors