Genetic health risks in children of assisted reproductive technology

Carmen Sapienza, a geneticist at Temple University School of Medicine, studies the impact of the environment on genes by comparing one type of chromosome modification, called "DNA methylation" between children conceived in the traditional fashion with children born as a result of assisted reproduction.

"We found that 5-10 percent of these chromosome modifications were different in children born through assisted reproduction, and this altered the expression of nearby genes," he said. "But we have not yet distinguished whether this is caused by assisted reproductive technologies or other factors such as the couple's infertility."

Because some of the affected genes are involved in the development of fat tissue and the metabolism of glucose, Sapienza believes it will be important to monitor these children long-term to determine whether they have higher rates of obesity or diabetes.

He notes that even though there were measurable differences in DNA methylation and gene expression between the two groups, only a small fraction of the assisted reproduction children were found to be outside the "normal" range.

Provided by Temple University (news : web)