Study: How some cancers become leukemia
July 17, 2006U.S. researchers say they've found how cancer-triggering oncogenes allow blood cells to self-renew and become leukemia stem cells.
Dr. Scott Armstrong and colleagues at the Harvard Medical School introduced an oncogene into mouse blood-cell producing progenitor cells and then isolated cancer stem cells from the resulting leukemias. Comparing the profile of active genes in those cells with the blood cells from which they had developed showed the oncogene ramps up a specific subset of the genes active also in normal blood stem cells.
Those genes confer on cells the ability to self-renew and a subset of the genes is also expressed in human leukemia associated with certain oncogenes, the researchers said.
Thus, although cancer is thought to start often in normal stem cells, at least some oncogenic events can drive cancer from other cells by switching on stem-cell genes, Armstrong said.
The study appears in the journal Nature.
Copyright 2006 by United Press International
-
Parkinson's disease: Study of live human neurons reveals the disease's genetic origins
Feb 07, 2012 |
5 / 5 (4) |
1
-
Researchers develop gene therapy to boost brain repair for demyelinating diseases
Feb 09, 2012 |
5 / 5 (5) |
0
-
Unusual alliances enable movement
Feb 08, 2012 |
4.5 / 5 (2) |
0
-
Scientists use an old theory to discover new targets in the fight against breast cancer
Feb 07, 2012 |
5 / 5 (2) |
0
-
New study makes key finding in stem cell self-renewal
Feb 06, 2012 |
4.7 / 5 (3) |
0
-
Engineers build first sub-10-nm carbon nanotube transistor
Feb 01, 2012 |
4.9 / 5 (31) |
30
-
Something old, something new: Evolution and the structural divergence of duplicate genes
Jan 31, 2012 |
4.6 / 5 (7) |
1
-
The hidden nanoworld of ice crystals: Revealing the dynamic behavior of quasi-liquid layers
Jan 30, 2012 |
5 / 5 (3) |
1
-
Stock market network reveals investor clustering
Jan 27, 2012 |
3.9 / 5 (23) |
8
-
Of microchemistry and molecules: Electronic microfluidic device synthesizes biocompatible probes
Jan 26, 2012 |
5 / 5 (1) |
0
More news stories
Study finds that anti-diabetic medication can prevent the long-term effects of maternal obesity
In a study to be presented today at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting, in Dallas, Texas, researchers will report findings that show that short therapy with the anti-diabetic medication ...
10 hours ago |
5 / 5 (1) |
1
Steroid injections prove effective in treatment of lumbar disc herniations
The use of epidural steroid injections may be a more efficient treatment option for lumbar disc herniations, according to research presented today at the American Orthopaedic Society for Sports Medicine's Specialty Day in ...
10 hours ago |
not rated yet |
0
Amateur football players not always keen on returning to play after ACL injuries
Despite the known success rates of reconstructive Anterior Cruciate Ligament (ACL) surgery, the number of high school and collegiate football players returning to play may not be as high as anticipated, say researchers presenting ...
10 hours ago |
not rated yet |
0
Study finds elevated levels of cell-free DNA in first trimester do not predict preeclampsia
In a study to be presented today at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting, in Dallas, Texas, researchers will report findings that indicate that elevated levels of cell-free DNA in ...
10 hours ago |
not rated yet |
0
PRP treatment aids healing of elbow injuries say researchers
As elbow injuries continue to rise, especially in pitchers, procedures to help treat and get players back in the game quickly have been difficult to come by. However, a newer treatment called platelet rich plasma (PRP) may ...
10 hours ago |
5 / 5 (1) |
0
Walney offshore wind farm is world's biggest (for now)
(PhysOrg.com) -- The Walney wind farm on the Irish Sea--characterized by high tides, waves and windy weather--officially opened this week. The farm is treated in the press as a very big deal as the Walney ...
GPS court ruling leaves US phone tracking unclear
A US Supreme Court decision requiring a warrant to place a GPS device on the car of a criminal suspect leaves unresolved the bigger issue of police tracking using mobile phones, legal experts say.
Europeans protest controversial Internet pact
Tens of thousands of people marched in protests in more than a dozen European cities Saturday against a controversial anti-online piracy pact that critics say could curtail Internet freedom.
Europe stakes billion-dollar bet on new rocket
A pencil-slim rocket is scheduled to lift into space from South America on Monday, carrying a billion-dollar bet that Europe can grab a juicy slice of the market to place satellites in low orbit.
Netflix settlement trims 14 pct off 4Q earnings
(AP) -- Netflix pressed the rewind button on its fourth-quarter earnings after settling allegations that the video subscription service violated a consumer-privacy law.
Elbow position not a predictor of injury
Elbow position alone appeared to not affect injury rates and performance in college-level, male pitchers say researchers presenting at the American Orthopaedic Society for Sports Medicine's Specialty Day in San Francisco, ...
