Inhaled steroids may not be enough for some children with asthma

May 22, 2007

Some children may not be able to keep their asthma under control even if they consistently report using inhaled corticosteroids, a mainstay of asthma treatment, suggests a new study presented at the American Thoracic Society 2007 International Conference, on Wednesday, May 23.

The study of 914 children with mild to moderate asthma found that over a one-year period, children who reported consistent inhaled steroid use were 20% less likely to report having well-controlled asthma compared with those not using any inhaled steroids. This finding held even when the severity of the children’s asthma was taken into account.

“There may be several reasons for our findings; It is possible that some children are genetically less responsive to steroids,” says researcher Gregory Sawicki, M.D. of Children’s Hospital in Boston. “In addition to issues of medication adherence and inability to completely control for differences in underlying asthma, severity can never be completely ruled out.”

Several studies of adults with asthma have suggested that even rigorous use of inhaled steroids doesn’t lead to well controlled asthma in all adults, Dr. Sawicki noted. “But this issue hasn’t been looked at closely in children,” he said. “Further studies are needed to see what is different about children who don’t respond to steroids, to see if there is a way to predict whether a child will respond to inhaled steroids.”

Of the 914 children in the study, inhaled steroids were recommended for 435 who had persistent asthma, meaning they had symptoms on a regular basis. Among children who weren’t recommended for inhaled steroid treatment, most reported well-controlled asthma. Among those recommended for inhaled steroid treatment, 44% reported consistently using the medicine; 35% said they intermittently used the medicine and 21% said they didn’t use it at all.

“The majority of children with mild asthma are less likely to have symptoms as they get older and may not need to be on daily steroids,” Dr. Sawicki said. “The flip side is that if a child has poor asthma control, the parents and doctor need to make sure the child is adhering to their inhaled steroid treatment. But variation in response to inhaled steroids, as other medications, is well described.”

The data comes from the Child Asthma Management Program Continuation Study (CAMPCS), one of the largest groups of children with mild to moderate asthma in the nation who have been followed over 10 years. “This study gives us a good sense of real-world practice in asthma management,” Dr. Sawicki says. “The children’s care is not directed by anyone in the study; it’s an observation of what goes on when the children’s care is directed by their own physicians.”

Source: American Thoracic Society


Rank not rated yet
Tags

Relevant PhysicsForums posts

More news stories

Study finds that anti-diabetic medication can prevent the long-term effects of maternal obesity

In a study to be presented today at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting, in Dallas, Texas, researchers will report findings that show that short therapy with the anti-diabetic medication ...

Medicine & Health / Health

created 11 hours ago | popularity 5 / 5 (1) | comments 1

Steroid injections prove effective in treatment of lumbar disc herniations

The use of epidural steroid injections may be a more efficient treatment option for lumbar disc herniations, according to research presented today at the American Orthopaedic Society for Sports Medicine's Specialty Day in ...

Medicine & Health / Health

created 11 hours ago | popularity not rated yet | comments 0

Amateur football players not always keen on returning to play after ACL injuries

Despite the known success rates of reconstructive Anterior Cruciate Ligament (ACL) surgery, the number of high school and collegiate football players returning to play may not be as high as anticipated, say researchers presenting ...

Medicine & Health / Health

created 11 hours ago | popularity not rated yet | comments 0

Study finds elevated levels of cell-free DNA in first trimester do not predict preeclampsia

In a study to be presented today at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting, in Dallas, Texas, researchers will report findings that indicate that elevated levels of cell-free DNA in ...

Medicine & Health / Other

created 11 hours ago | popularity not rated yet | comments 0

PRP treatment aids healing of elbow injuries say researchers

As elbow injuries continue to rise, especially in pitchers, procedures to help treat and get players back in the game quickly have been difficult to come by. However, a newer treatment called platelet rich plasma (PRP) may ...

Medicine & Health / Other

created 11 hours ago | popularity 5 / 5 (1) | comments 0


Walney offshore wind farm is world's biggest (for now)

(PhysOrg.com) -- The Walney wind farm on the Irish Sea--characterized by high tides, waves and windy weather--officially opened this week. The farm is treated in the press as a very big deal as the Walney ...

GPS court ruling leaves US phone tracking unclear

A US Supreme Court decision requiring a warrant to place a GPS device on the car of a criminal suspect leaves unresolved the bigger issue of police tracking using mobile phones, legal experts say.

Europeans protest controversial Internet pact

Tens of thousands of people marched in protests in more than a dozen European cities Saturday against a controversial anti-online piracy pact that critics say could curtail Internet freedom.

Europe stakes billion-dollar bet on new rocket

A pencil-slim rocket is scheduled to lift into space from South America on Monday, carrying a billion-dollar bet that Europe can grab a juicy slice of the market to place satellites in low orbit.

Netflix settlement trims 14 pct off 4Q earnings

(AP) -- Netflix pressed the rewind button on its fourth-quarter earnings after settling allegations that the video subscription service violated a consumer-privacy law.

Elbow position not a predictor of injury

Elbow position alone appeared to not affect injury rates and performance in college-level, male pitchers say researchers presenting at the American Orthopaedic Society for Sports Medicine's Specialty Day in San Francisco, ...