OHSU Cancer Institute researcher identifies protein marker for prostate cancer survival

Beer's research will be presented Friday, June 1 (CST) at the 43rd annual meeting of the American Society of Clinical Oncologists in Chicago. Julie Graff, M.D., OHSU Cancer Institute member, division of hematology and medical oncology, will present the research.

It has been known that cancer causes an inflammatory response. This research also suggests that inflammation may play an important role in driving prostate cancer progression and resistance to therapy.

"While sometimes inflammation may slow the cancer, an increasing body of evidence suggests that cancer can take advantage of the inflammatory response and the inflammatory cytokines released by the immune reaction may in fact fuel cancer progression. To the extent that our hypothesis proves true, C-reactive protein may be reflecting the overall intensity of the inflammation," Beer said.

The finding that higher CRP is associated with shorter survival and a lower probability of response to chemotherapy is a result of a secondary analysis of inflammatory markers in subjects enrolled in the ASCENT study, a large Phase 2 clinical trial that evaluated treatment with docetaxel and DN-101, a high dose formulation of calcitriol or docetaxel with placebo. This analysis included subjects from both groups. The analyses were supported by Novacea Inc., the sponsor of the ASCENT study. This new finding was in collaboration with Novacea.

The results of ASCENT were published February 20, 2007 in the Journal of Clinical Oncology. . The most significant finding from the trial of advanced prostate cancer subjects was the magnitude of DN-101 (Asentar) used in combination with docetaxel (Taxotere), on survival, producing an estimated 49 percent improvement in survival (p=0.035), while reducing the frequency of serious adverse events by 34 percent (p=0.023) as compared to the use of Taxotere alone.

Because this was the first time CRP has been linked with both response and survival in advanced prostate cancer patients receiving chemotherapy, it will be important to confirm this finding in an independent data set before this can become a routine blood test for men with advanced prostate cancer, Beer said.

Source: Oregon Health & Science University