A 'door' into the mitochondrial membrane

Mitochondria—the organelles responsible for energy production in human cells—were once free-living organisms that found their way into early eukaryotic cells over a billion years ago. Since then, they have merged seamlessly ...

New 'triggers' in an essential pathway to destroy microRNAs

In a study from the lab of Whitehead Institute Member David Bartel, researchers have identified genetic sequences that can lead to the degradation of cellular regulators called microRNAs in the fruit fly Drosophila melanogaster. ...

Germ cells move like tiny bulldozers

During fruit fly embryo formation, primordial germ cells—the stem cells that will later form eggs and sperm—must travel from the far end of the embryo to their final location in the gonads. Part of the primordial germ ...

Video: 'Mapping' the body with single-cell RNA sequencing

While nearly every cell in the body contains identical genetic instructions packaged in DNA, there is flexibility on how that genetic information is expressed and in turn translated through RNA to create proteins, the building ...

Metabolic protein explains how flies choose 'healthy' food

Many animals, including humans, have a preference for nutrient-balanced diets. Among all essential nutrients, multicellular organisms need to consume the building blocks of proteins, called amino acids, in order to build ...

How proteins assemble may have underappreciated role in disease

Thanks to advances in genomics in recent decades, researchers now know the genetic mutations responsible for many diseases. However, researchers often still do not know how the mutation leads to the disease—what it changes ...

How the body senses an essential amino acid

A new paper from Whitehead Institute researchers reveals how mice sense an essential amino acid called leucine, which many people get from eating fish, eggs, or nuts. Down the line, the work could inform research into creating ...

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