Penn researchers link cell's protein recycling systems

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Neurodegeneration in a fruit fly eye. Normal or wild type eye (left) appears uniformly structured. Eye in fruit fly model of Alzheimers disease (middle) appears rough and deformed. Eye in fruit fly model of Alzheimers disease in which extra HDAC6 pro ...
Neurodegeneration in a fruit fly eye. Normal or wild type eye (left) appears uniformly structured. Eye in fruit fly model of Alzheimer's disease (middle) appears rough and deformed. Eye in fruit fly model of Alzheimer's disease in which extra HDAC6 protein is expressed (right) appears uniformly structured as in wild type. Credit: J. Paul Taylor, MD, PhD, University of Pennsylvania School of Medicine

Many age-related neurological diseases are associated with defective proteins accumulating in nerve cells, suggesting that the cell’s normal disposal mechanisms are not operating correctly. Now, researchers at the University of Pennsylvania School of Medicine have discovered a molecular link between the cell’s two major pathways for breaking down proteins and have succeeded in using this link to rescue neurodegenerative diseases in a simple animal model. The study appears this week in Nature.


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