Tumors use enzyme to recruit regulatory T-cells and suppress immune response

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Patients with breast cancer show early evidence of their tumors creating a safe environment for themselves within the lymph nodes by up-regulating cells expressing IDO (in red). Credit: Medical College of Georgia
Patients with breast cancer show early evidence of their tumors creating a safe environment for themselves within the lymph nodes by up-regulating cells expressing IDO (in red). Credit: Medical College of Georgia

One way tumors fly under the radar of the immune system is by using IDO, an enzyme used by fetuses to help avoid rejection, to recruit powerful regulatory T cells that turn down the immune response, researchers say.


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