Gene triggers obsessive compulsive disorder-like syndrome in mice

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SAPAP3 knockout mouse has a raw bald patch on its face from compulsive grooming behavior. Credit: Guoping Feng Ph.D. Duke University
SAPAP3 knockout mouse has a raw bald patch on its face from compulsive grooming behavior. Credit: Guoping Feng, Ph.D., Duke University

Using genetic engineering, researchers have created an obsessive-compulsive disorder (OCD) - like set of behaviors in mice and reversed them with antidepressants and genetic targeting of a key brain circuit. The study, by National Institutes of Health (NIH) -funded researchers, suggests new strategies for treating the disorder.


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