Toxic shock: immune system's anthrax link

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Artists impression of the perforin-like protein Plu-MACPF. Australian scientists have found that this protein belongs to an ancient and lethal toxin family previously only found in bacteria. (Acrylic on canvas). Credit: Carla Chinni
Artist's impression of the perforin-like protein Plu-MACPF. Australian scientists have found that this protein belongs to an ancient and lethal toxin family previously only found in bacteria. (Acrylic on canvas). Credit: Carla Chinni

Human immune proteins crucial for fighting cancer, viruses and bacterial infections belong to an ancient and lethal toxin family previously only found in bacteria, Australian researchers have found.
These proteins, called perforins, are related to bacterial toxins that cause diseases such as anthrax, gas gangrene and scarlet fever. The discovery was made by a team led by Professor James Whisstock and Dr Michelle Dunstone from Monash University’s School of Biomedical Sciences.


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