Venous origin of the mammalian lymphatic vasculature

In the October 1 issue of G&D, Dr. Guillermo Oliver (St. Jude Children’s Research Hospital) and colleagues present new evidence to resolve a century-old debate over the origin of the mammalian lymphatic vasculature. Understanding the development of the lymphatic vasculature is integral to understanding its function in both health (mediating immunity and maintaining tissue fluid levels) and disease (lymphedema and spreading tumor metastasis).