Aging gracefully requires taking out the trash
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Top: The image shows the brain of a normal, 15-day old fly. Bottom: Damaged proteins tagged for degradation (bright, red stain) start to accumulate in the brains of 15-day old flies in which the process of autophagy has been suppressed. These flies live only half as long as their normal counterparts. Credit: Tim Finley
Suppressing a cellular cleanup-mechanism known as autophagy can accelerate the accumulation of protein aggregates that leads to neural degeneration. In an upcoming issue of
Autophagy, scientists at the Salk Institute for Biological Studies report for the first time that the opposite is true as well: Boosting autophagy in the nervous system of fruit flies prevented the age-dependent accumulation of cellular damage in neurons and promoted longevity.
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