Nanotechnology innovation may revolutionize gene detection in a single cell

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On the left is an AFM image of DNA nanoarrays bound to their RNA targets at 1500nm x 1500nm scale. The zoom-in images (150nm x 150nm scale) on the right clearly show the barcode (white dots) that identifies the nanoarray and the RNA hybridization sig ...
On the left is an AFM image of DNA nanoarrays bound to their RNA targets at 1500nm x 1500nm scale. The zoom-in images (150nm x 150nm scale) on the right clearly show the barcode (white dots) that identifies the nanoarray and the RNA hybridization signal on the DNA nanoarray (white bar). Credit: Yonggang Ke

Scientists at Arizona State University’s Biodesign Institute have developed the world’s first gene detection platform made up entirely from self-assembled DNA nanostructures. The results, appearing in the January 11 issue of the journal Science, could have broad implications for gene chip technology and may also revolutionize the way in which gene expression is analyzed in a single cell.


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