Researchers map signaling networks that control neuron function

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Mouse neuron showing multiple neurites with fan-shaped growth cones. Credit: UCSD School of Medicine
Mouse neuron showing multiple neurites with fan-shaped growth cones. Credit: UCSD School of Medicine

In the first large-scale proteomics study of its kind, researchers at the University of California, San Diego School of Medicine have mapped thousands of neuronal proteins to discover how they connect into complex signaling networks that guide neuron function. Their research – using quantitative mass spectrometry, computational software and bioinformatics to match the proteins to their cellular functions – may lead to a better understanding of brain development, neurodegenerative diseases, and spinal cord regeneration.


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