PARP-1 rules! Scientists find how a protein binds to genes and regulates human genome

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Atomic force microscopy images of chromatin binding by PARP-1 and histone H1 genome-binding proteins that regulate gene expression across the genome. Credit: David Wacker
Atomic force microscopy images of chromatin binding by PARP-1 and histone H1, genome-binding proteins that regulate gene expression across the genome. Credit: David Wacker

Out of chaos, control: Cornell University molecular biologists have discovered how a protein called PARP-1 binds to genes and regulates their expression across the human genome. Knowing where PARP-1 is located and how it works may allow scientists to target this protein while battling common human diseases. Their research is in a study published today in the journal Science.


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