Insight into HIV's 'on-off' switch shows promise for therapy, understanding cellular decisions

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These immune cells infected with a genetically engineered HIV are expressing the green fluorescent protein. The cells exhibit great cell-to-cell variation (noise) despite being genetically identical to each other. Credit: University of California - S ...
These immune cells, infected with a genetically engineered HIV, are expressing the green fluorescent protein. The cells exhibit great cell-to-cell variation (noise) despite being genetically identical to each other. Credit: University of California - San Diego

Researchers at the University of California, San Diego and Oak Ridge National Laboratory have discovered how a genetic circuit in HIV controls whether the virus turns on or stays dormant, and have succeeded in forcing the virus towards dormancy, a finding that shows promise as an avenue for HIV therapy. Their findings are published in the March 16 issue of the journal Nature Genetics.


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